Background: Monoallelic mutations in the gene encoding bone morphogenetic protein receptor
2 (Bmpr2) are the main genetic risk factor for heritable pulmonary arterial hypertension (…

Beyond the major gene BMPR2, several new genes predisposing to PAH have been identified
during the last decade. Recently, preliminary evidence of the involvement of the KDR …

Pulmonary veno-occlusive disease (PVOD) occurs in humans either as a heritable form (hPVOD)
due to biallelic inactivating mutations of EIF2AK4 (encoding GCN2) or as a sporadic …

Vitamin D (VitD) receptor regulates the expression of several genes involved in signaling
pathways affected in pulmonary hypertension (PH). VitD deficiency is highly prevalent in PH, …

Idiopathic pulmonary arterial hypertension (IPAH) is a complex disease associated with
vascular remodeling and a proliferative disorder in pulmonary artery smooth muscle cells (…

Rationale: Pulmonary hypertension (PH) has been described in patients treated with
leflunomide. Objectives: To assess the association between leflunomide and PH. Methods: We …

Background Pulmonary arterial hypertension (PAH) is a progressive disease characterised
by pro-proliferative and anti-apoptotic phenotype in vascular cells, leading to pulmonary …

Pulmonary arterial hypertension (PAH), is a fatal disease characterized by a pseudo-malignant
phenotype. We investigated the expression and the role of the receptor tyrosine kinase …

Background Pulmonary arterial hypertension (PAH) encompasses a group of diseases
characterized by raised pulmonary vascular resistance, resulting from vascular remodelling and …

Trichloroethylene exposure is a major risk factor for pulmonary veno-occlusive disease. We
demonstrated that trichloroethylene alters the endothelial barrier integrity, at least in part, …