Essentials • How platelets organize their α‐granule cargo and use their canalicular system
remains controversial. • Past structural studies were limited due to small sampling volumes or …

Obesity affects more than 650 million adults worldwide and is a major risk factor for a variety
of serious comorbidities. The prevalence of obesity has tripled in the past forty years and …

Obesity increases incidence and severity of asthma but the molecular mechanisms are not
completely understood. Hyperinsulinemia potentiates vagally induced bronchoconstriction in …

Obesity-induced asthma responds poorly to all current pharmacological interventions,
including steroids, suggesting that classic, eosinophilic inflammation is not a mechanism. Since …

Increased insulin is associated with obesity-related airway hyperreactivity and asthma. We
tested whether the use of metformin, an antidiabetic drug used to reduce insulin resistance, …

Children born to obese mothers are prone to develop asthma and airway hyperresponsiveness,
but the mechanisms behind this are unclear. Here we developed a mouse model of …

Asthma susceptibility is influenced by environmental, genetic, and epigenetic factors. DNA
methylation is one form of epigenetic modification that regulates gene expression and is both …

Ret is the receptor tyrosine kinase for the glial cell line-derived neurotrophic factor (GDNF)
family of neuronal growth factors. Upon activation by GDNF, Ret is rapidly polyubiquitinated …

For MD/DO-PhD trainees, who pursue an extended training pathway with formal learning in
both clinical and research settings, the COVID-19 pandemic has brought a unique set of …

Incorporation of melanoma prevention behaviors into daily lifestyles is difficult. Data suggest
that high school educational programs on skin cancer prevention can be successful and …