Rationale: Airway smooth muscle (ASM) plays a key role in airway hyperresponsiveness (AHR)
but it is unclear whether its contractility is intrinsically changed in asthma. Objectives: To …

Airway smooth muscle (ASM) orientation and morphology determine the ability of the muscle
to constrict the airway. In asthma, ASM mass is increased, but it is unknown whether ASM …

Constriction of airways during asthmatic exacerbation is the result of airway smooth muscle (ASM)
contraction. Although it is generally accepted that ASM is hypercontractile in asthma, …

Heaves is a naturally occurring equine disease that shares many similarities with human
asthma, including reversible antigen-induced bronchoconstriction, airway inflammation, and …

Cystic fibrosis (CF) is an autosomal-recessive disease caused by mutations in the CF
transmembrane conductance regulator gene. Many patients with CF have asthma-like symptoms …

It remains unclear whether airway smooth muscle (ASM) mechanics is altered in asthma.
While efforts have originally focussed on contractile force, some evidence points to an …

Length adaptation in airway smooth muscle (ASM) is attributed to reorganization of the
cytoskeleton, and in particular the contractile elements. However, a constantly changing lung …

We present a systematic quantitative analysis of power-law force relaxation and investigate
logarithmic superposition of force response in relaxed porcine airway smooth muscle (ASM) …

Objective: This paper presents a force control scheme for brief isotonic holds in an
isometrically contracted muscle tissue, with minimal overshoot and settling time to measure its …

Background Smooth muscle has the distinctive ability to maintain force for long periods of
time and at low energy costs. While it is generally agreed that this property, called the latch-…