Lung adenocarcinoma (LUAD)-derived Wnts increase cancer cell proliferative/stemness
potential, but whether they impact the immune microenvironment is unknown. Here we show …

The lungs are frequently affected by cancer metastasis. Although NRAS mutations have
been associated with metastatic potential, their exact role in lung homing is incompletely …

Background Survival after curative resection of early-stage lung adenocarcinoma (LUAD)
varies and prognostic biomarkers are urgently needed. Methods Large-format tissue samples …

Malignant pleural mesothelioma (MPM) arises from mesothelial cells lining the pleural
cavity of asbestos‐exposed individuals and rapidly leads to death. MPM harbors loss‐of‐function …

Integrin-linked kinase (ILK) forms a heterotrimeric protein complex with PINCH and PARVIN
(IPP) in Focal Adhesions (FAs) that acts as a signaling platform between the cell and its …

Simple Summary Kirsten rat sarcoma virus (KRAS)-mutant cancers are frequent, metastatic,
lethal, and largely undruggable. The aim of this study was to investigate the pathways …

Conventional chemotherapy leads to severe adverse effects since it involves systemic
administration of toxic drugs at high dosage. Unlike traditional chemotherapeutics, calcium …

A comprehensive characterization of lung adenocarcinoma ( LADC ) clinical features is
currently missing. We prospectively evaluated Caucasian patients with early‐stage LADC . …

Mast cells (MC) have been identified in human lung adenocarcinoma (LADC) tissues, but their
functional role has not been investigated in vivo. For this, we applied three mouse models …

Epigenetic approaches in direct correlation with assessment of critical genetic mutations in
non-small cell lung cancer (NSCLC) are currently very intensive, as the epigenetic …