DYX1C1 has been associated with dyslexia and neuronal migration in the developing
neocortex. Unexpectedly, we found that deleting exons 2–4 of Dyx1c1 in mice caused a …

Using a whole-exome sequencing strategy, we identified recessive CCNO (encoding cyclin
O) mutations in 16 individuals suffering from chronic destructive lung disease due to …

Reduced generation of multiple motile cilia (RGMC) is a rare mucociliary clearance disorder.
Affected persons suffer from recurrent infections of upper and lower airways because of …

Defects of motile cilia cause primary ciliary dyskinesia (PCD), characterized by recurrent
respiratory infections and male infertility. Using whole-exome resequencing and high-…

Primary ciliary dyskinesia (PCD) is a rare genetic disorder leading to recurrent respiratory
tract infections. High-speed video-microscopy analysis (HVMA) of ciliary beating, currently the …

A diverse family of cytoskeletal dynein motors powers various cellular transport systems,
including axonemal dyneins generating the force for ciliary and flagellar beating essential to …

The motive forces for ciliary movement are generated by large multiprotein complexes
referred to as outer dynein arms (ODAs), which are preassembled in the cytoplasm prior to …

Primary ciliary dyskinesia (PCD) is a genetically heterogeneous, autosomal-recessive
disorder, characterized by oto-sino-pulmonary disease and situs abnormalities. PCD-causing …

Defects in motile cilia and sperm flagella cause primary ciliary dyskinesia (PCD), characterized
by chronic airway disease, infertility, and left-right body axis disturbance. Here we report …

Hydrocephalus is one of the most prevalent form of developmental central nervous system (CNS)
malformations. Cerebrospinal fluid (CSF) flow depends on both heartbeat and body …