Vaccines play a critical role in combating the COVID-19 pandemic. Future control of the
pandemic requires improved vaccines with high efficacy against newly emerging SARS-CoV-2 …

Mycobacterium tuberculosis remains one of the top microbial killers of humans causing∼ 2
million deaths annually. More than 90% of the 2 billion individuals infected never develop …

The molecular mechanisms that control innate immune cell trafficking during chronic infection
and inflammation, such as in tuberculosis (TB), are incompletely understood. During active …

Successful host defense against numerous pulmonary infections depends on bacterial clearance
by polymorphonuclear leukocytes (PMNs); however, excessive PMN accumulation can …

General interest in the biological functions of IFN type I in Mycobacterium tuberculosis (Mtb)
infection increased after the recent identification of a distinct IFN gene expression signature …

As a hallmark of tuberculosis (TB), Mycobacterium tuberculosis (MTB) induces granulomatous
lung lesions and systemic inflammatory responses during active disease. Molecular …

Neutrophil trafficking to sites of inflammation is essential for the defense against bacterial and
fungal infections, but also contributes to tissue damage in TH 17-mediated autoimmunity. …

The cation channel transient receptor potential vanilloid (TRPV) 4 is expressed in endothelial
and immune cells; however, its role in acute lung injury (ALI) is unclear. The functional …

Vaccine-associated enhanced respiratory disease (VAERD) is a severe complication for
some respiratory infections. To investigate the potential for VAERD induction in coronavirus …

For coronavirus disease 2019 (COVID-19), effective and well-understood treatment options
are still scarce. Since vaccine efficacy is challenged by novel variants, short-lasting immunity…