Disordered breathing during sleep is associated with acute, unfavorable effects on
cardiovascular physiology, but few studies have examined its postulated association with …

Background— Clinic-based observational studies in men have reported that obstructive sleep
apnea is associated with an increased incidence of coronary heart disease. The objective …

Background Sleep-disordered breathing is a common condition associated with adverse
health outcomes including hypertension and cardiovascular disease. The overall objective of …

Rationale: Although obstructive sleep apnea is associated with physiological perturbations
that increase risk of hypertension and are proatherogenic, it is uncertain whether sleep …

Background Children with asthma who live in the inner city are exposed to multiple indoor
allergens and environmental tobacco smoke in their homes. Reductions in these triggers of …

The Sleep Heart Health Study (SHHS) is a prospective cohort study designed to investigate
obstructive sleep apnea (OSA) and other sleep-disordered breathing (SDB) as risk factors …

SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) as its cellular receptor, as do
SARS-CoV and the coronavirus NL63. 1 Higher ACE2 expression increases in vitro …

Background— DNA methylation leaves a long-term signature of smoking exposure and is one
potential mechanism by which tobacco exposure predisposes to adverse health outcomes…

This study assessed the extent to which sleep-disordered breathing (SDB), difficulty initiating
and maintaining sleep (DIMS), and excessive daytime sleepiness (EDS) were associated …

Spirometric measures of lung function are heritable traits that reflect respiratory health and
predict morbidity and mortality. We meta-analyzed genome-wide association studies for two …