Utility of endobronchial ultrasound-guided transbronchial needle aspiration in patients with tuberculous intrathoracic lymphadenopathy: a multicentre study

…, M Wickremasinghe, A Lalvani, RC Rintoul, G Santis… - Thorax, 2011 - thorax.bmj.com
Background Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)
has emerged as an important tool for the diagnosis and staging of lung cancer but its role …

Identification of contact residues and definition of the CAR-binding site of adenovirus type 5 fiber protein

…, PW Roelvink, I Kovesdi, BJ Sutton, G Santis - Journal of …, 2000 - Am Soc Microbiol
The binding of adenovirus (Ad) fiber knob to its cellular receptor, the coxsackievirus and Ad
receptor (CAR), promotes virus attachment to cells and is a major determinant of Ad tropism. …

Challenges in molecular testing in non-small-cell lung cancer patients with advanced disease

CT Hiley, J Le Quesne, G Santis, R Sharpe… - The Lancet, 2016 - thelancet.com
Lung cancer diagnostics have progressed greatly in the previous decade. Development of
molecular testing to identify an increasing number of potentially clinically actionable genetic …

Integrin alpha5beta1-mediated adenovirus infection is enhanced by the integrin-activating antibody TS2/16

E Davison, RM Diaz, IR Hart, G Santis… - Journal of …, 1997 - Am Soc Microbiol
Adenovirus internalization generally has been accepted to involve an interaction of the
adenoviral penton base protein with alpha(v)beta3 and alpha(v)beta5 cell surface integrins. In …

Diagnosis and Subtyping of De Novo and Relapsed Mediastinal Lymphomas by Endobronchial Ultrasound Needle Aspiration

…, R Breen, PA Fields, G Santis - American journal of …, 2013 - atsjournals.org
Rationale: The current management of lymphoma requires accurate diagnosis and subtyping
of de novo lymphoma and of relapsed or refractory lymphoma in known cases. The role of …

[HTML][HTML] Screening for EGFR and KRAS Mutations in Endobronchial Ultrasound Derived Transbronchial Needle Aspirates in Non-Small Cell Lung Cancer Using …

G Santis, R Angell, G Nickless, A Quinn, A Herbert… - PLoS …, 2011 - journals.plos.org
EGFR mutations correlate with improved clinical outcome whereas KRAS mutations are
associated with lack of response to tyrosine kinase inhibitors in patients with non-small cell lung …

[HTML][HTML] The transcriptional signature of active tuberculosis reflects symptom status in extra-pulmonary and pulmonary tuberculosis

…, J Banchereau, D Chaussabel, R Breen, G Santis… - PloS one, 2016 - journals.plos.org
Background Mycobacterium tuberculosis infection is a leading cause of infectious death
worldwide. Gene-expression microarray studies profiling the blood transcriptional response of …

[HTML][HTML] The architecture of EGFR's basal complexes reveals autoinhibition mechanisms in dimers and oligomers

…, PMP van Bergen En Henegouwen, G Santis… - Nature …, 2018 - nature.com
Our current understanding of epidermal growth factor receptor (EGFR) autoinhibition is based
on X-ray structural data of monomer and dimer receptor fragments and does not explain …

Mutations in the DG loop of adenovirus type 5 fiber knob protein abolish high-affinity binding to its cellular receptor CAR

…, PW Roelvink, I Kovesdi, BJ Sutton, G Santis - Journal of …, 1999 - Am Soc Microbiol
The amino acid residues in adenovirus type 5 (Ad5) fiber that interact with its cellular receptor,
the coxsackie B virus and Ad receptor (CAR), have not been defined. To investigate this, …

[HTML][HTML] CAR: A key regulator of adhesion and inflammation

E Ortiz-Zapater, G Santis, M Parsons - … journal of biochemistry & cell biology, 2017 - Elsevier
The coxsackie and adenovirus receptor (CAR) is a transmembrane receptor that plays a key
role in controlling adhesion between adjacent epithelial cells. CAR is highly expressed in …