[HTML][HTML] High purity isolation of low density neutrophils casts doubt on their exceptionality in health and disease
GR Hardisty, F Llanwarne, D Minns, JL Gillan… - Frontiers in …, 2021 - frontiersin.org
Low density neutrophils (LDNs) are described in a number of inflammatory conditions, cancers
and infections and associated with immunopathology, and a mechanistic role in disease. …
and infections and associated with immunopathology, and a mechanistic role in disease. …
Role of the B allele of influenza A virus segment 8 in setting mammalian host range and pathogenicity
…, BW Jagger, Y Ligertwood, GR Hardisty… - Journal of …, 2016 - Am Soc Microbiol
Two alleles of segment 8 (NS) circulate in nonchiropteran influenza A viruses. The A allele
is found in avian and mammalian viruses, but the B allele is viewed as being almost …
is found in avian and mammalian viruses, but the B allele is viewed as being almost …
[HTML][HTML] Human cystic fibrosis monocyte derived macrophages display no defect in acidification of phagolysosomes when measured by optical nanosensors
SM Law, SJ Stanfield, GR Hardisty, I Dransfield… - Journal of Cystic …, 2020 - Elsevier
Background Defective macrophage phagolysosomal acidification is implicated in numerous
lung diseases including Cystic Fibrosis (CF) and may contribute to defective pathogen killing…
lung diseases including Cystic Fibrosis (CF) and may contribute to defective pathogen killing…
[HTML][HTML] Concurrent Infection With the Filarial Helminth Litomosoides sigmodontis Attenuates or Worsens Influenza A Virus Pathogenesis in a Stage-Dependent …
GR Hardisty, JA Knipper, A Fulton, J Hopkins… - Frontiers in …, 2022 - frontiersin.org
Filarial helminths infect approximately 120 million people worldwide initiating a type 2
immune response in the host. Influenza A viruses stimulate a virulent type 1 pro-inflammatory …
immune response in the host. Influenza A viruses stimulate a virulent type 1 pro-inflammatory …
CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages
An intense, nonresolving airway inflammatory response leads to destructive lung disease in
cystic fibrosis (CF). Dysregulation of macrophage immune function may be a key facet …
cystic fibrosis (CF). Dysregulation of macrophage immune function may be a key facet …
Ivacaftor modifies cystic fibrosis neutrophil phenotype in subjects with R117H residual function CFTR mutations
GR Hardisty, SM Law, S Carter… - European …, 2021 - Eur Respiratory Soc
… Drafting of manuscript: GR Hardisty, SM Law and RD Gray. Conflict of interest: GR Hardisty
has nothing to disclose. … Support statement: Supported by an investigator initiated award …
has nothing to disclose. … Support statement: Supported by an investigator initiated award …
[HTML][HTML] Macrophages from gut-corrected CF mice express human CFTR and lack a pro-inflammatory phenotype
JL Gillan, GR Hardisty, DJ Davidson, RD Gray - Journal of Cystic Fibrosis, 2022 - Elsevier
Macrophages represent prominent immune orchestrators of cystic fibrosis (CF) inflammation
and, as such, are an ever-increasing focus of CF research with several reports of intrinsic …
and, as such, are an ever-increasing focus of CF research with several reports of intrinsic …
[HTML][HTML] SERS microsensors for pH measurements in the lumen and ECM of stem cell derived human airway organoids
WH Skinner, N Robinson, GR Hardisty… - Chemical …, 2023 - pubs.rsc.org
Patient derived organoids have the potential to improve the physiological relevance of in vitro
disease models. However, the 3D architecture of these self-assembled cellular structures …
disease models. However, the 3D architecture of these self-assembled cellular structures …
[HTML][HTML] Neutrophil-dependent Mitochondrial DNA Release Associated With Extracellular Trap Formation in Inflammatory Bowel Disease
Background and Aims Inflammatory bowel disease (IBD) is associated with increased
circulating damage-associated molecular patterns, in particular, the highly pro-inflammatory …
circulating damage-associated molecular patterns, in particular, the highly pro-inflammatory …
[PDF][PDF] Human cystic fibrosis monocyte derived macrophages display no defect in acidification of phagolysosomes when measured by optical nanosensors
CJ Campbell, RD Gray - 2019 - researchgate.net
Sheonagh M. Law a, 1, Samuel J. Stanfield b, 1, Gareth R. Hardisty a, Ian Dransfield a, Colin
J. Campbell b, 1, Robert D. Gray a,⁎, 1 a Centre for Inflammation Research, The Queen's …
J. Campbell b, 1, Robert D. Gray a,⁎, 1 a Centre for Inflammation Research, The Queen's …