Importance Preliminary clinical trials have demonstrated that endobronchial coils compress
emphysematous lung tissue and may improve lung function, exercise tolerance, and …

Importance Therapeutic options for severe emphysema are limited. Lung volume reduction
using nitinol coils is a bronchoscopic intervention inducing regional parenchymal volume …

Free iron in lung can cause the generation of reactive oxygen species, an important factor in
chronic obstructive pulmonary disease (COPD) pathogenesis. Iron accumulation has been …

Background ANDHI was done to assess the efficacy of benralizumab, including onset of effect
and impact on health-related quality of life (HRQOL), exacerbation rate, lung function, and …

Lung cancer remains the first cause of cancer-related death despite many therapeutic innovations,
including immune checkpoint inhibitors (ICI). ICI are now well used in daily practice at …

Chronic obstructive pulmonary disease (COPD) is the chronic respiratory disease with the
most important burden on public health in terms of morbidity, mortality and health costs. For …

Background Dyspnea is very frequent in obese subjects. However, its assessment is complex
in clinical practice. The modified Medical Research Council scale (mMRC scale) is largely …

Background The lung volume reduction (LVR) coil is a minimally invasive bronchoscopic
nitinol device designed to reduce hyperinflation and improve elastic recoil in severe …

The coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is an international public health emergency …

Background Hedgehog (HH) pathway is constantly under scrutiny in the context of organ
development. Lung morphogenesis requires HH signalling which participates thereafter to the …