The performance of a predictive model is overestimated when simply determined on the sample
of subjects that was used to construct the model. Several internal validation methods are …

Background The Onchocerciasis Control Program (OCP) in West Africa has been closed down
at the end of 2002. All subsequent control will be transferred to the participating countries …

Purpose Early detection of hepatocellular carcinoma (HCC) is essential for improved prognosis
and long-term survival. To date, screening for HCC depends on serological testing (alpha…

A logistic regression model may be used to provide predictions of outcome for individual
patients at another centre than where the model was developed. When empirical data are …

We analyzed six spirometric data sets collected in the Netherlands, Austria, the United
Kingdom, Spain, and Italy. The objectives were to establish whether (1) it was possible to …

This study sought to determine the contribution of neighborhood socioeconomic status to all-cause
mortality and to explore its correlates. As part of the longitudinal “Gezondheid en …

Purpose: There is ongoing debate about whether testing low-risk genes at multiple loci will
be useful in clinical care and public health. We investigated the usefulness of multiple genetic …

Background: In lung cancer CT screening, participants often have an indeterminate screening
result at baseline requiring a follow-up CT. In subjects with either an indeterminate or a …

Although with earlier detection of prostate cancer more men face the long‐term
consequences of primary treatment, studies on the impact of treatment on long‐term health‐related …

The long-term effects of lung cancer computed tomography (CT) screening on health-related
quality of life (HRQoL) have not yet been investigated. In the Dutch–Belgian Randomised …