The Global Initiative for Asthma (GINA) Strategy Report provides clinicians with an annually
updated evidence-based strategy for asthma management and prevention, which can be …

Biologic Therapies for Severe Asthma Patients with severe asthma are at increased risk for a
decreased quality of life, fixed airway obstruction, hospitalization, and death. Biologics may …

Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome associated
with abnormal inflammatory immune responses of the lung to noxious particles and gases. …

Background Some patients with severe asthma have frequent exacerbations associated with
persistent eosinophilic inflammation despite continuous treatment with high-dose inhaled …

Background Elevated numbers of blood eosinophils are a risk factor for asthma exacerbations.
Reslizumab is a humanised anti-interleukin 5 monoclonal antibody that disrupts …

Spirometric measures of lung function are heritable traits that reflect respiratory health and
predict morbidity and mortality. We meta-analyzed genome-wide association studies for two …

Chronic obstructive pulmonary disease (COPD) is characterised by chronic inflammation of
the airways and progressive destruction of lung parenchyma, a process that in most cases is …

To investigate the role of IL‐4 in vivo in allergic asthma, we developed a murine model of
allergen‐induced airway inflammation. Repealed daily exposures of actively immunised C57BL…

… Guy G Brusselle1, … Correspondence to Dr Guy G Brusselle, Department of Respiratory
Medicine, Ghent University Hospital, De Pintelaan 185, Ghent B-9000, Belgium; guy.brusselle{at}…

We examined common variation in asthma risk by conducting a meta-analysis of worldwide
asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of …