Stress or heat shock proteins (HSPs) 70 and 90 are powerful chaperones whose expression
is induced in response to a wide variety of physiological and environmental insults. These …

Heat shock proteins (HSPs) are chaperones that catalyze the proper folding of nascent
proteins and the refolding of denatured proteins. The ubiquitin-proteasome system is an error-…

… arises between the globular monomeric form, named G-actin which is soluble, and the
polymerized form, named F-actin. A large number of proteins interact with G- and/or F-actin to …

… (F–G) Liver fibrosis was assessed by quantification of hepatic hydroxyproline content (F)
and the fraction of Sirius red positive area (G). (H) Expression of Acta2 (αSMA). Data are …

Background & aims In advanced chronic liver disease (ACLD), deregulated hepatic
necroinflammatory processes play a key role in the development of liver microvascular dysfunction, …

The heat‐shock protein 27 (HSP27) is up‐regulated in tumor cells and released in their
microenvironment. Here, we show that extracellular HSP27 has a proangiogenic effect …

IVA337 is a pan‐peroxisome proliferator‐activated receptor (PPAR) agonist with moderate
and well‐balanced activity on the three PPAR isoforms (α, γ, δ). PPARs are regulators of lipid …

Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by myofibroblast
proliferation. Transition of epithelial/mesothelial cells into myofibroblasts [epithelial‐to‐…

Here, we describe the identification and synthesis of novel indole sulfonamide derivatives
that activate the three peroxisome proliferator activated receptor (PPAR) isoforms. Starting …

Extracellular heat shock protein HSP90α was reported to participate in tumor cell growth,
invasion, and metastasis formation through poorly understood signaling pathways. Herein, we …