We present here the results obtained within the framework of an EU funded project aimed to
develop and validate alternative metabolic activating systems to be used in short-term …

Mutations in the coding sequences and splice sites of the p53 tumor suppressor gene are a
common finding in almost every kind of human cancer. The number of human tumors that …

Purpose: Repair of radiation-induced DNA damage is believed to play a critical role in the
development of adverse reactions in radiotherapy patients. Constitutive mRNA expression of …

The prognosis for lung cancer patients treated with chemotherapy is poor. Single nucleotide
polymorphisms (SNPs) in matrix metalloproteinase (MMP) genes could influence treatment …

Introduction: We investigated the single-nucleotide polymorphism C-938A in the apoptotic
gene BCL-2 to assess the potential impact as a genetic marker for response to chemotherapy …

Six primary and 10 secondary benzylic alcohols derived from polycycic aromatic hydrocarbons
were tested for mutagemcity in Salmonella typhimurium TA98 in the presence of varying …

… 3) demonstrated only 1/30 of the expression of STa in females (G. … Details of the study
will be published elsewhere (G. Werle-Schneider et al., manuscript in preparation). --, not …

Transcription profiling is used as an in vivo method for predicting the mode-of-action class
of nongenotoxic carcinogens. To set up a reliable in vitro short-term test system DNA …

Rat liver cytosolic hydroxysteroid sulfotransferases form highly reactive sulfurk acid esters
from some benzylic alcohols, such as 1-hydroxymethylpyrene. In this study we examined the …

It has been demonstrated recently that certain repetitive sequences and even expressed
single‐copy genes are capable of retrotransposition, but little is known about the endogenous …