Digital technologies and adherence in respiratory diseases: the road ahead

…, AL Dima, J Weinman, G Safioti… - European …, 2018 - Eur Respiratory Soc
Outcomes for patients with chronic respiratory diseases remain poor despite the development
of novel therapies. In part, this reflects the fact that adherence to therapy is low and …

[HTML][HTML] Digital health technology in asthma: a comprehensive scoping review

G Mosnaim, G Safioti, R Brown, M DePietro… - The Journal of Allergy …, 2021 - Elsevier
Background A variety of digital intervention approaches have been investigated for asthma
therapy during the last decade, with different levels of interactivity and personalization, with a …

[HTML][HTML] Effect of inhalation profile and throat geometry on predicted lung deposition of budesonide and formoterol (BF) in COPD: an in-vitro comparison of Spiromax …

…, G Safioti, JR Keegstra, G Gopalan - International journal of …, 2015 - Elsevier
Successful delivery of inhalation medication to the lungs can be affected by the inhalation
manoeuvre used. Conventional in-vitro testing of the emitted dose from a dry powder inhaler (…

[HTML][HTML] Effectiveness of a digital inhaler system for patients with asthma: a 12-week, open-label, randomized study (CONNECT1)

FCL Hoyte, GS Mosnaim, L Rogers, G Safioti… - The Journal of Allergy …, 2022 - Elsevier
Background The albuterol Digihaler (albuterol 90 μg/dose) transmits data wirelessly to a smart
device application, which synchronizes with a Digital Health Platform to store and transfer …

Asthma control is associated with economic outcomes, work productivity and health-related quality of life in patients with asthma

LK Lee, K Ramakrishnan, G Safioti… - BMJ open …, 2020 - bmjopenrespres.bmj.com
Background The objective of this analysis was to examine the association between asthma
control (based on Asthma Control Test (ACT) responses) and healthcare resource utilisation (…

Investigating the accuracy of the Digihaler, a new electronic multidose dry-powder inhaler, in measuring inhalation parameters

…, K Kastango, E Calderon, T Li, G Safioti - Journal of Aerosol …, 2022 - liebertpub.com
Background: The Digihaler ® is a Food and Drug Administration-approved, digital multidose
dry powder inhaler with an integrated electronic module that provides patients and health …

[HTML][HTML] Effectiveness of a maintenance and reliever digihaler system in asthma: 24-week randomized study (CONNECT2)

GS Mosnaim, FCL Hoyte, G Safioti, R Brown… - The Journal of Allergy …, 2024 - Elsevier
Background Digital health tools have been shown to help address challenges in asthma
control, including inhaler technique, treatment adherence, and short-acting β 2 -agonist overuse…

A predictive machine learning tool for asthma exacerbations: results from a 12-week, open-label study using an electronic multi-dose dry powder inhaler with …

…, T Li, T Hill, RW Brown, G Safioti - Journal of Asthma …, 2022 - Taylor & Francis
Purpose Machine learning models informed by sensor data inputs have the potential to provide
individualized predictions of asthma deterioration. This study aimed to determine if data …

Expert Nordic perspectives on the potential of novel inhalers to overcome unmet needs in the management of obstructive lung disease

…, A Østrem, I Pasternack, G Safioti… - European clinical …, 2015 - Taylor & Francis
The effective self-management of obstructive lung disease is dependent upon the patient
achieving good inhaler technique. However, many current inhalers are complicated to use, …

[HTML][HTML] Asthma control and COPD symptom burden in patients using fixed-dose combination inhalers (SPRINT study)

…, I Cerveri, C Gonzalez, G Safioti… - NPJ primary care …, 2020 - nature.com
Previous studies have found suboptimal control of symptom burden to be widespread among
patients with asthma and chronic obstructive pulmonary disease (COPD). The Phase IV …