User profiles for G. Ruiter

Graham de Ruiter

Assistant Professor of Chemistry, Technion - Israel Institute of Technology
Verified email at technion.ac.il
Cited by 1445

The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis

M Verheij, GA Ruiter, SF Zerp… - Radiotherapy and …, 1998 - Elsevier
Ionizing radiation, like a variety of other cellular stress factors, initiates apoptosis, or
programmed cell death, in many cell systems. This mode of radiation-induced cell kill should be …

Dysregulated renin–angiotensin–aldosterone system contributes to pulmonary arterial hypertension

…, L Tu, ML Handoko, S Rain, G Ruiter… - American journal of …, 2012 - atsjournals.org
Rationale: Patients with idiopathic pulmonary arterial hypertension (iPAH) often have a low
cardiac output. To compensate, neurohormonal systems such as the renin–angiotensin–…

Iron deficiency is common in idiopathic pulmonary arterial hypertension

G Ruiter, S Lankhorst, A Boonstra… - European …, 2011 - Eur Respiratory Soc
The aims of this study were to assess the prevalence of iron deficiency in idiopathic pulmonary
arterial hypertension (IPAH) and investigate whether oral iron supplementation has …

Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase–Akt/PKB survival pathway

GA Ruiter, SF Zerp, H Bartelink… - Anti-cancer …, 2003 - journals.lww.com
Synthetic alkyl-lysophospholipids (ALPs) represent a new class of anti-tumor agents that
target cell membranes and induce apoptosis. However, the exact mechanisms by which ALPs …

Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis

GA Ruiter, M Verheij, SF Zerp… - International Journal of …, 2001 - Elsevier
Synthetic alkyl-lysophospholipids (ALPs, also referred to as ether-phospholipids) have been
studied as antitumor agents for more than a decade. Classical examples of these ALPs …

Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis

GA Ruiter, SF Zerp, H Bartelink, WJ van Blitterswijk… - Cancer research, 1999 - AACR
Alkyl-lysophospholipids (ALPs) represent a new class of antitumor drugs that induce apoptotic
cell death in a variety of tumor cell lines. Although their precise mechanism of action is …

Intravenous iron therapy in patients with idiopathic pulmonary arterial hypertension and iron deficiency

G Ruiter, E Manders, CM Happé, I Schalij… - Pulmonary …, 2015 - journals.sagepub.com
… In addition, LV and RV free wall mass index remained stable (LV: 59 ± 15 g/m 2 before vs.
62 ± 17 g/m 2 after; RV: 51 ± 29 g/m 2 before vs. 56 ± 31 g/m 2 after; both NS; Table S4). …

Right ventricular failure in idiopathic pulmonary arterial hypertension is associated with inefficient myocardial oxygen utilization

YY Wong, G Ruiter, M Lubberink… - Circulation: Heart …, 2011 - Am Heart Assoc
Background— In idiopathic pulmonary arterial hypertension (IPAH), increased right ventricular
(RV) power is required to maintain cardiac output. For this, RV O 2 consumption (MVO 2 ) …

Iron deficiency in systemic sclerosis patients with and without pulmonary hypertension

G Ruiter, IJ Lanser, FS de Man… - …, 2014 - academic.oup.com
Objectives. SSc-associated pulmonary hypertension (SSc-PH) has a worse prognosis compared
with SSc without PH (SSc-nonPH). Iron deficiency (ID) was previously associated with …

[HTML][HTML] Malnutrition in pulmonary arterial hypertension: a possible role for dietary intervention

CT Kwant, G Ruiter… - Current opinion in …, 2019 - journals.lww.com
Pulmonary arterial hypertension (PAH) is a lung disease characterized by increased blood
pressure (BP) in the pulmonary circulation ultimately causing right ventricular (RV) failure (…