Managing comorbidities in COPD

G Hillas, F Perlikos, I Tsiligianni… - International journal of …, 2015 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality
worldwide. Age and smoking are common risk factors for COPD and other illnesses, often …

Acute exacerbation of COPD: is it the “stroke of the lungs”?

G Hillas, F Perlikos, N Tzanakis - International journal of chronic …, 2016 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is one of the top five major causes of
morbidity and mortality worldwide. Despite worldwide health care efforts, costs, and medical …

[HTML][HTML] Asthma-COPD overlap syndrome: recent insights and unanswered questions

E Fouka, AI Papaioannou, G Hillas… - Journal of Personalized …, 2022 - mdpi.com
The term asthma-COPD overlap (ACO) has been used to identify a heterogeneous condition
in which patients present with airflow limitation that is not completely reversible and clinical …

C-reactive protein and procalcitonin as predictors of survival and septic shock in ventilator-associated pneumonia

G Hillas, T Vassilakopoulos, P Plantza… - European …, 2010 - Eur Respiratory Soc
… The samples were centrifuged at 500×g for 10 min and the plasma was aliquoted and stored
at -70C until analysed in a single batch. Circulating levels of CRP were measured using an …

Clinical, functional and inflammatory characteristics in patients with paucigranulocytic stable asthma: comparison with different sputum phenotypes

…, G Papatheodorou, E Papathanassiou, G Hillas… - Allergy, 2017 - Wiley Online Library
Background According to induced sputum cell count, four different asthma phenotypes have
been recognized (eosinophilic, neutrophilic, mixed and paucigranulocytic). The aim of this …

[HTML][HTML] Persistent airflow obstruction in patients with asthma: characteristics of a distinct clinical phenotype

…, G Patentalakis, A Papaporfyriou, G Hillas… - Respiratory …, 2015 - Elsevier
Background Some patients with asthma present persistent airflow limitation but their clinical
and inflammatory characteristics have not been extensively described. In this study we …

The role of non-invasive modalities for assessing inflammation in patients with non-cystic fibrosis bronchiectasis

S Tsikrika, K Dimakou, AI Papaioannou, G Hillas… - Cytokine, 2017 - Elsevier
Introduction Bronchiectasis is a heterogeneous entity, taking into account clinical characteristics,
inflammatory response, effectiveness of treatment and frequency of exacerbations. In …

[HTML][HTML] ROSE: radiology, obstruction, symptoms and exposure–a Delphi consensus definition of the association of COPD and bronchiectasis by the EMBARC …

…, JR Hurst, PL Paggiaro, S Ferri, G Hillas… - ERJ open …, 2021 - Eur Respiratory Soc
Introduction The coexistence of COPD and bronchiectasis seems to be common and
associated with a worse prognosis than for either disease individually. However, no definition of …

Increased levels of osteopontin in sputum supernatant in patients with COPD

…, G Papatheodorou, E Konstantellou, G Hillas… - Chest, 2014 - Elsevier
BACKGROUND Osteopontin (OPN) is a phosphorylated acidic glycoprotein that can function
as both an extracellular matrix molecule and a cytokine. Published data support that OPN is …

[HTML][HTML] Post-COVID-19 interstitial lung disease: Insights from a machine learning radiographic model

…, S Makrodimitri, S Chrysikos, G Hillas… - Frontiers in …, 2023 - frontiersin.org
Introduction Post-acute sequelae of COVID-19 seem to be an emerging global crisis.
Machine learning radiographic models have great potential for meticulous evaluation of post-…