Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma

…, M McAlary, A Fowler-Taylor, G Della Cioppa… - Journal of allergy and …, 2001 - Elsevier
Background: A recombinant humanized anti-IgE mAb, omalizumab, forms complexes with
free IgE, blocking its interaction with mast cells and basophils; as a consequence, it might be …

Cytoplasmic inhibition of carotenoid biosynthesis with virus-derived RNA.

…, J Donson, G Della-Cioppa… - Proceedings of the …, 1995 - National Acad Sciences
The carotenoid biosynthetic pathway in higher plants was manipulated by using an RNA
viral vector. A cDNA encoding phytoene synthase and a partial cDNA encoding phytoene …

The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics

…, J Thirlwell, N Gupta, G Della Cioppa - European …, 2001 - Eur Respiratory Soc
The clinical benefit and steroid-sparing effect of treatment with the anti-immunoglobulin-E (IgE)
antibody, omalizumab, was assessed in patients with moderate-to-severe allergic asthma…

Efficacy and safety of a recombinant anti‐immunoglobulin E antibody (omalizumab) in severe allergic asthma

…, H Fox, J Thirlwell, GD Cioppa… - Clinical & …, 2004 - Wiley Online Library
Background Patients with severe asthma are often inadequately controlled on existing anti‐asthma
therapy, constituting an unmet clinical need. Objective This randomized, double‐blind…

The effect of treatment with omalizumab, an anti‐IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma

…, S Wenzel, H Fox, S Hedgecock, M Blogg, GD Cioppa - Allergy, 2005 - Wiley Online Library
Background: Patients with severe persistent asthma who are inadequately controlled despite
treatment according to current asthma management guidelines have a significant unmet …

Inhaled formoterol dry powder versus ipratropium bromide in chronic obstructive pulmonary disease

…, MH Thomson, D Till, G Della Cioppa - American journal of …, 2001 - atsjournals.org
We compared the effectiveness of inhaled formoterol with that of ipratropium in the treatment
of chronic obstructive pulmonary disease (COPD). After a 2-wk run-in period, 780 patients …

Effect of omalizumab on symptoms of seasonal allergic rhinitis: a randomized controlled trial

…, A Racine, N Gupta, R Fick, G Della Cioppa… - Jama, 2001 - jamanetwork.com
ContextSeasonal allergic rhinitis is a common IgE-mediated disorder that produces
troublesome symptoms. A recombinant humanized monoclonal anti-IgE antibody (omalizumab) …

Recombinant humanized mAb-E25, an anti-IgE mAb, in birch pollen–induced seasonal allergic rhinitis

…, K Champain, J Thirlwell, G Della Cioppa… - Journal of allergy and …, 2000 - Elsevier
Background: Allergic rhinitis is a common condition often requiring treatment. Objective: We
evaluated whether recombinant humanized (rhu)mAb-E25, a recombinant humanized …

Hemagglutination inhibition antibody titers as a correlate of protection for inactivated influenza vaccines in children

…, M Knuf, G Del Giudice, G Della Cioppa… - The Pediatric …, 2011 - journals.lww.com
Methods: A total of 4707 influenza vaccine–naive healthy children 6 to 72 months old were
randomized in a ratio of 2: 2: 1 to receive 2 doses of MF-59–adjuvanted influenza vaccine (…

Translocation of the precursor of 5-enolpyruvylshikimate-3-phosphate synthase into chloroplasts of higher plants in vitro

G Della-Cioppa, SC Bauer, BK Klein… - Proceedings of the …, 1986 - National Acad Sciences
… The translation products (100 ,ul) were passed through a Sephadex G-50 column (1ml)
prior to enzyme assay. The enzyme assay contained 5 ,ul of translation products in a 50 ,l …