Mutational inactivation of VHL is the earliest genetic event in the majority of clear cell renal
cell carcinomas (ccRCC), leading to accumulation of the HIF-1α and HIF-2α transcription …

Chronic obstructive pulmonary disease (COPD) is characterised by a progressive loss of
lung tissue. Inducing repair processes within the adult diseased lung is of major interest and …

Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct
transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of …

CD8 + effector T (T E ) cell proliferation and cytokine production depends on enhanced
glucose metabolism. However, circulating T cells continuously adapt to glucose fluctuations …

During allogeneic hematopoietic cell transplantation (alloHCT), nonhematopoietic cell
interleukin-33 (IL-33) is augmented and released by recipient conditioning to promote type 1 …

Chronic lung diseases (CLDs), such as chronic obstructive pulmonary disease, interstitial
lung disease, and lung cancer, are among the leading causes of morbidity globally and …

Acute myeloid leukemia (AML) relapse after allogeneic hematopoietic cell transplantation (allo-HCT)
has a dismal prognosis. We found that T cells of patients relapsing with AML after …

Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and
idiopathic pulmonary fibrosis (IPF), are characterized by regional extracellular matrix (ECM) …

Fever can provide a survival advantage during infection. Metabolic processes are sensitive
to environmental conditions, but the effect of fever on T cell metabolism is not well …

Despite progress in use of decellularized lung scaffolds in ex vivo lung bioengineering
schemes, including use of gels and other materials derived from the scaffolds, the detailed …