User profiles for Françoise Van Bambeke

Françoise Van Bambeke

Université catholique de Louvain
Verified email at uclouvain.be
Cited by 13281

Antibiotic efflux pumps

F Van Bambeke, E Balzi, PM Tulkens - Biochemical pharmacology, 2000 - Elsevier
Active efflux from procaryotic as well as eucaryotic cells strongly modulates the activity of a
large number of antibiotics. Effective antibiotic transport has now been observed for many …

[HTML][HTML] Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium

…, A Malfroot, PM Tulkens, F Van Bambeke - Clinical microbiology …, 2007 - Elsevier
Pseudomonas aeruginosa is a major cause of nosocomial infections. This organism shows
a remarkable capacity to resist antibiotics, either intrinsically (because of constitutive …

[HTML][HTML] Intracellular Staphylococcus aureus persisters upon antibiotic exposure

…, JY Coppée, C Wolz, T Tenson, F Van Bambeke - Nature …, 2020 - nature.com
Bacterial persister cells are phenotypic variants that exhibit a transient non-growing state
and antibiotic tolerance. Here, we provide in vitro evidence of Staphylococcus aureus …

[HTML][HTML] Quinolones in 2005: an update

F Van Bambeke, JM Michot, J Van Eldere… - Clinical Microbiology …, 2005 - Elsevier
Quinolones are one of the largest classes of antimicrobial agents used worldwide. This
review considers the quinolones that are available currently and used widely in Europe (…

[PDF][PDF] Cellular pharmacodynamics and pharmacokinetics of antibiotics: current views and perspectives

F Van Bambeke, M Barcia-Macay, S Lemaire… - Current Opinion in Drug …, 2006 - Citeseer
The treatment of intracellular infections requires the use of antibiotics presenting appropriate
cellular pharmacokinetic and pharmacodynamic properties. These properties, however, …

Intracellular pharmacodynamics of antibiotics

…, MP Mingeot-Leclercq, F Van Bambeke… - Infectious Disease …, 2003 - id.theclinics.com
Treatment of intracellular bacterial infection remains both a medical and economic challenge.
Pathogens thriving or maintaining themselves in cells, or simply taking transient refuge …

Renaissance of antibiotics against difficult infections: focus on oritavancin and new ketolides and quinolones

F Van Bambeke - Annals of medicine, 2014 - Taylor & Francis
Lipoglycopeptide, ketolide, and quinolone antibiotics are currently in clinical development,
with specific advantages over available molecules within their respective classes. The …

Pharmacodynamic Evaluation of the Intracellular Activities of Antibiotics against Staphylococcus aureus in a Model of THP-1 Macrophages

…, PM Tulkens, F Van Bambeke - Antimicrobial agents …, 2006 - Am Soc Microbiol
The pharmacodynamic properties governing the activities of antibiotics against intracellular
Staphylococcus aureus are still largely undetermined. Sixteen antibiotics of seven different …

[HTML][HTML] Glycopeptide antibiotics: from conventional molecules to new derivatives

F Van Bambeke, Y Van Laethem, P Courvalin… - Drugs, 2004 - Springer
Vancomycin and teicoplanin are still the only glycopeptide antibiotics available for use in
humans. Emergence of resistance in enterococci and staphylococci has led to restriction of …

Antibiotic efflux pumps in prokaryotic cells: occurrence, impact on resistance and strategies for the future of antimicrobial therapy

F Van Bambeke, Y Glupczynski, P Plesiat… - Journal of …, 2003 - academic.oup.com
Originally described in bacteria, drug transporters (or efflux pumps) are now recognized as
major determinants in the modulation of the accumulation and efflux of antibacterials in …