Although the occurrence of loss of genetic material in hepatocellular carcinoma (HCC) has
been documented both by cytogenetic analysis and by monitoring of allelic losses, a global …

Transplantation of hepatocytes is a promising alternative to liver transplantation for the treatment
of severe liver diseases. However, this approach is hampered by the shortage of donor …

Introduction La classification des pneumopathies interstitielles diffuses (PID) idiopathiques
comporte sept entités anatomocliniques, dont le diagnostic nécessite une approche …

Mesothelioma is a rare disease less than 0.3% of cancers in France, very aggressive and
resistant to the majority of conventional therapies. Asbestos exposure is nearly the only …

The main impediment to effective ex vivo liver gene therapy of metabolic diseases is the lack
of experimental work on large animals to resolve such important issues as effective gene …

Background & Aims: In nonalcoholic fatty liver disease (NAFLD), the distinction between
steatosis and steatohepatitis (NASH) and the assessment of the severity of the disease rely on …

Pulmonary arterial hypertension is a severe complication of connective tissue diseases. It is
currently well established that pulmonary arterial hypertension associated with connective …

We have developed a new assay, ISET (isolation by size of epithelial tumor cells), which allows
the counting and the immunomorphological and molecular characterization of circulating …

Background Idiopathic pulmonary fibrosis is a chronic progressive disorder with a poor
prognosis. Methods We conducted a double-blind, randomized, placebo-controlled multicenter …

Dendritic-cell (DC) trafficking and function in tumors is poorly characterized, with studies
confined to myeloid DCs (DC1s). Tumors inhibit DC1 migration and function, likely hindering …