Endothelial cell (EC) activation has been suspected of triggering a group of rare and dismal
complications that can occur after allogeneic hematopoietic stem cell transplantation (HSCT)…

At least 10% of patients with interstitial lung disease present monogenic lung fibrosis
suspected on familial aggregation of pulmonary fibrosis, specific syndromes or early age of …

Background A single-group, phase 1–2 study indicated that eltrombopag improved the
efficacy of standard immunosuppressive therapy that entailed horse antithymocyte globulin (ATG) …

Despite major improvements in allogeneic hematopoietic cell transplantation over the past
decades, corticosteroid-refractory (SR) acute (a) and chronic (c) graft-versus-host disease (…

Ravulizumab (ALXN1210), a new complement C5 inhibitor, provides immediate, complete,
and sustained C5 inhibition. This phase 3, open-label study assessed the noninferiority of …

Bone marrow (BM) failure (BMF) in children and young adults is often suspected to be
inherited, but in many cases diagnosis remains uncertain. We studied a cohort of 179 patients (…

The recent application of whole exome or whole genome sequencing unveiled a plethora of
germline variants predisposing to myeloid disorders, particularly myelodysplastic neoplasms…

Individuals with acute myeloid leukemia (AML) harboring an internal tandem duplication (ITD)
in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after allogeneic …

Interleukin 10 (IL-10)–producing B cells (regulatory B cells [Bregs]) regulate autoimmunity in
mice and humans, and a regulatory role of IL-10–producing plasma cells has been …

Germline DDX41 mutations are involved in familial myelodysplastic syndromes (MDSs) and
acute myeloid leukemias (AMLs). We analyzed the prevalence and characteristics of DDX41…