Avoiding destruction by immune cells is a hallmark of cancer, yet how tumors ultimately
evade control by natural killer (NK) cells remains incompletely defined. Using global …

CD96, CD226 (DNAM-1) and TIGIT belong to an emerging family of receptors that interact
with nectin and nectin-like proteins. CD226 activates natural killer (NK) cell–mediated …

Tissue-resident memory T (T RM ) cells are non-recirculating cells that exist throughout the
body. Although T RM cells in various organs rely on common transcriptional networks to …

Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer,
ILC2s can harbor both pro-tumorigenic and anti-tumorigenic functions, but we know little …

Extracellular adenosine is a key immunosuppressive metabolite that restricts activation of
cytotoxic lymphocytes and impairs antitumor immune responses. Here, we show that …

Differentiation of naïve CD4 + T cells into functionally distinct T helper (T H ) subsets is
crucial for the orchestration of immune responses. Because of extensive heterogeneity and …

Immune ‘checkpoint' inhibitors can increase the activity of tumor-resident cytotoxic lymphocytes
and have revolutionized cancer treatment. Current therapies block inhibitory pathways in …

Natural killer (NK) cells are important in innate immunity, first described as guardians for the
detection and clearance of transformed or virus‐infected cells. Later, this cell type was …

Natural killer (NK) cell activity is essential for initiating antitumor responses and may be
linked to immunotherapy success. NK cells and other innate immune components could be …

Antigen-specific CD8 + T cells in chronic viral infections and tumors functionally deteriorate,
a process known as exhaustion. Exhausted T cells are sustained by precursors of exhausted …