Attenuation of Virulence by Disruption of the Mycobacterium tuberculosis erp Gene

…, D Ensergueix, P Chavarot, F Thouron… - Science, 1998 - science.org
… tuberculosis–infected, J774 murine macrophage sections incubated with anti-ERP serum
previously adsorbed against purified ERP-6HIS (E) or anti-ERP sera (F); arrowheads in (F) …

Development of Mixed Th1/Th2 Type Immune Response and Protection Against Mycobacterium tuberculosis After Rectal or Subcutaneous Immunization of Newborn and Adult …

…, P Chavarot, MA Nahori, F Thouron… - Scandinavian …, 2002 - Wiley Online Library
Cell‐mediated immunity plays a key role in containing the growth of Mycobacterium
tuberculosis in the host. The induction of an antibody response or a mixed cell‐mediated and …

The First-in-Human Synthetic Glycan-Based Conjugate Vaccine Candidate against Shigella

…, J Westdijk, M Stork, O Ophorst, F Thouron… - ACS Central …, 2022 - ACS Publications
Shigella, the causative agent of shigellosis, is among the main causes of diarrheal diseases
with still a high morbidity in low-income countries. Relying on chemical synthesis, we …

A synthetic carbohydrate conjugate vaccine candidate against shigellosis: improved bioconjugation and impact of alum on immunogenicity

…, TH Kim, C Guerreiro, F Thouron… - Bioconjugate …, 2016 - ACS Publications
Conjugation chemistry is among the most important parameters governing the efficacy of
glycoconjugate vaccines. High robustness is required to ensure high yields and batch to batch …

Induction of type-IIA secretory phospholipase A2 in animal models of acute lung injury

…, Y Wu, M Alaoui-El-Azher, F Thouron… - European …, 2003 - Eur Respiratory Soc
The aim of this study was to evaluate the presence of type-II secretory phospholipase A2 (sPLA2-IIA)
in alveolar space and its possible role in the destruction of surfactant in three rat …

Effect of surfactant on pulmonary expression of type IIA PLA2 in an animal model of acute lung injury

Y Wu, M Singer, F Thouron… - … of Physiology-Lung …, 2002 - journals.physiology.org
We previously showed that the seminatural surfactant Curosurf inhibits the in vitro synthesis
of secretory type IIA phospholipase A 2 (sPLA 2 -IIA) in alveolar macrophages (AM). These …

Effects of Mycobacterium bovis BCG on the development of allergic inflammation and bronchial hyperresponsiveness in hyper-IgE BP2 mice vaccinated as newborns

MA Nahori, M Lagranderie, J Lefort, F Thouron… - Vaccine, 2001 - Elsevier
Asthma may result from excessive Th-2 response in children not previously exposed to Th-1-inducing
infections. We tested the hypothesis that BCG vaccination in Th-2-susceptible …

Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity

…, FX Theillet, C Guerreiro, F Thouron, F Nato… - Organic & …, 2014 - pubs.rsc.org
Synthetic functional mimics of the O-antigen from Shigella flexneri 2a are seen as promising
vaccine components against endemic shigellosis. Herein, the influence of the …

Detailed investigation of the immunodominant role of O‐antigen stoichiometric O‐acetylation as revealed by chemical synthesis, immunochemistry, solution …

…, F Thouron, S Dartevelle, F Nato… - … A European Journal, 2016 - Wiley Online Library
Shigella flexneri 3a causes bacillary dysentery. Its O‐antigen has the {2)‐[α‐d‐Glcp‐(1→3)]‐α‐l‐Rhap‐(1→2)‐α‐l‐Rhap‐(1→3)‐[Ac→2]‐α‐l‐Rhap‐(1→3)‐[Ac→6]
≈40 % ‐β‐d‐…

[PDF][PDF] Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of Neisseria meningitidis

…, C Werts, L Peduto, MF d'Andon, F Thouron, F Nato… - Cell Host & Microbe, 2013 - cell.com
Neisseria meningitidis is a life-threatening human bacterial pathogen responsible for pneumonia,
sepsis, and meningitis. Meningococcal strains with reduced susceptibility to penicillin …