Nintedanib (BIBF1120) is a potent, oral, small-molecule tyrosine kinase inhibitor, also known
as a triple angiokinase inhibitor, inhibiting three major signaling pathways involved in …

Inhibition of tumor angiogenesis through blockade of the vascular endothelial growth factor (VEGF)
signaling pathway is a novel treatment modality in oncology. Preclinical findings …

BIBF 1000 is a small molecule inhibitor targeting the receptor kinases of platelet-derived
growth factor (PDGF), basic fibroblast growth factor and vascular endothelial growth factor, …

LETTERS TO NATURE Page 1 LETTERS TO NATURE to address the mechanisms of
substrate selectivity of this system. We have recently cloned several high-copy-number …

Mice lacking the AP-1 transcription factor c-Jun die around embryonic day E13.0 but little is
known about the cell types affected as well as the cause of embryonic lethality. Here we …

… Reaction progresses were usually monitored by TLC using Merck silica gel 60 F 254 plates
and UV light at 254 nm. All chromatographic purifications were conducted as MPLC using …

Cell adhesion molecules are considered to be pivotal elements required for proper embryo
development. The transmembrane glycoprotein CD44, which is expressed in numerous …

Human fibroblast activation protein (FAP), a member of the serine prolyl oligopeptidase family,
is a type II cell surface glycoprotein selectively expressed by fibroblastic cells in areas of …

The expression of Moloney murine leukemia virus and vectors derived from it is restricted in
undifferentiated mouse embryonal carcinoma and embryonal stem (ES) cells. We have …

Background & Aims: Impaired mucosal defense plays an important role in the pathogenesis
of Crohn’s disease (CD), one of the main subtypes of inflammatory bowel disease (IBD). …