… Fedor Berditchevski; Complexes of tetraspanins with integrins: more than meets the eye.
J Cell Sci 1 December 2001; 114 (23): 4143–4151. doi: https://doi.org/10.1242/jcs.114.23.4143 …

Introduction Breast cancer remains a significant scientific, clinical and societal challenge.
This gap analysis has reviewed and critically assessed enduring issues and new challenges …

Small transmembrane proteins of the tetraspanin superfamily are believed to function as the
main structural blocks of specialized membrane microdomains (referred to as tetraspanin‐…

Here we describe an association between α3β1 integrin and transmembrane-4 superfamily (TM4SF)
protein CD151. This association is maintained in relatively stringent detergents and …

… Indeed, we recently have found that distinct TM4SF proteins may differentially affect
phosphoinositide kinase activity associated with α3β1 integrin (Berditchevski, F., unpublished data). …

Enzymatic and immunochemical assays show a phosphatidylinositol 4-kinase in novel and
specific complexes with proteins (CD63 and CD81) of the transmembrane 4 superfamily (…

… A control antibody yielded only a few background proteins (lanes f and l). Integrin co-immunoprecipitation
experiments from several other cell lines (data not shown) yielded cell-surface …

The ‘metastasis suppressor' CD82/KAI-1, a member of the tetraspanin superfamily of
transmembrane proteins, is widely distributed in normal tissues [1], and has been shown to be …

Transmembrane proteins of the tetraspanin superfamily are assembled in multimeric complexes
on the cell surface. Spatial orientation of tetraspanins within these complexes may affect …

Here we identified several new integrin/TM4 protein complexes on the cell surface. By
immunoprecipitation using nonstringent conditions, and by reciprocal immunoprecipitation, we …