Pulmonary veno-occlusive disease

…, X Jaďs, L Savale, F Perros, E Nossent… - European …, 2016 - Eur Respiratory Soc
Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension (PH)
characterised by preferential remodelling of the pulmonary venules. In the current PH …

Divergent SARS‐CoV‐2‐specific T‐and B‐cell responses in severe but not mild COVID‐19 patients

…, NAM Kragten, BM Hogema, EJ Nossent… - European journal of …, 2020 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of
the current coronavirus disease 2019 (COVID‐19) pandemic. Understanding the immune …

[HTML][HTML] Clinical features and prognostic factors in Covid-19: a prospective cohort study

…, EHT Lim, N van Mourik, J Nellen, EJ Nossent… - …, 2021 - thelancet.com
Background Mortality rates are high among hospitalized patients with COVID-19, especially
in those intubated on the ICU. Insight in pathways associated with unfavourable outcome …

[HTML][HTML] Outcomes of hypofractionated high-dose radiotherapy in poor-risk patients with “ultracentral” non–small cell lung cancer

…, W Verbakel, E Bongers, S Hashemi, E Nossent… - Journal of Thoracic …, 2016 - Elsevier
Introduction We defined “ultracentral” lung tumors as centrally located non–small cell lung
cancers with planning target volumes overlapping the trachea or main bronchi. Increased …

Severely reduced diffusion capacity in idiopathic pulmonary arterial hypertension: patient characteristics and treatment responses

P Trip, EJ Nossent, FS de Man… - European …, 2013 - Eur Respiratory Soc
A subgroup of patients with idiopathic pulmonary arterial hypertension (IPAH) has severely
reduced diffusing capacity of the lung for carbon monoxide (D LCO ) and poor prognosis. …

Treatment-related toxicity in patients with early-stage non-small cell lung cancer and coexisting interstitial lung disease: a systematic review

H Chen, S Senan, EJ Nossent, RG Boldt… - International Journal of …, 2017 - Elsevier
Purpose Definitive treatment for patients with early-stage non-small cell lung cancer (ES-NSCLC)
is usually well tolerated. Patients with ES-NSCLC and coexisting interstitial lung …

Distinct cellular immune profiles in the airways and blood of critically ill patients with COVID-19

A Saris, TDY Reijnders, EJ Nossent, AR Schuurman… - Thorax, 2021 - thorax.bmj.com
Background Knowledge of the pathophysiology of COVID-19 is almost exclusively derived
from studies that examined the immune response in blood. We here aimed to analyse the …

Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial

…, M Muller, ECW Neefjes, EJ Nossent… - The Lancet …, 2021 - thelancet.com
Background The major complication of COVID-19 is hypoxaemic respiratory failure from
capillary leak and alveolar oedema. Experimental and early clinical data suggest that the …

[HTML][HTML] Indoleamine 2, 3‐dioxygenase (IDO)‐1 and IDO‐2 activity and severe course of COVID‐19

L Guo, B Schurink, E Roos, EJ Nossent… - The Journal of …, 2022 - Wiley Online Library
COVID‐19 is a pandemic with high morbidity and mortality. In an autopsy cohort of COVID‐19
patients, we found extensive accumulation of the tryptophan degradation products 3‐…

[HTML][HTML] CD169 defines activated CD14+ monocytes with enhanced CD8+ T cell activation capacity

…, E Rodríguez, A Saris, ES Zwart, EJ Nossent… - Frontiers in …, 2021 - frontiersin.org
Monocytes are antigen-presenting cells (APCs) that play diverse roles in promoting or
regulating inflammatory responses, but their role in T cell stimulation is not well defined. In …