This review surveys the data on the increase in the prevalence of asthma in recent decades
and finds evidence of a plateau in many Western countries. The authors examine the …

Asthma is responsible for considerable global morbidity and health-care costs. Substantial
progress was made against key outcomes such as hospital admissions with asthma and …

Numerous epidemiological studies have shown that children who grow up on traditional
farms are protected from asthma, hay fever and allergic sensitization. Early-life contact with …

Rationale: There is epidemiological evidence that the use of acetaminophen may increase
the risk of developing asthma. Objectives: To investigate the risk of asthma and other allergic …

OBJECTIVE. The aim of this study was to test the association between farm animal contact in
infancy and the development of juvenile Crohn disease and ulcerative colitis. METHODS. A …

Background In early life, the innate immune system can recognize both viable and nonviable
parts of microorganisms. Immune activation may direct the immune response, thus …

Background Susceptibility to asthma is influenced by genes and environment; implicated
genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful in …

Background A farming environment protects against development of asthma, hay fever, and
atopic sensitisation in children. We aimed to establish whether increased exposure to …

Asthma is caused by a combination of poorly understood genetic and environmental factors
1 , 2 . We have systematically mapped the effects of single nucleotide polymorphisms (SNPs…

Background Children who grow up in environments that afford them a wide range of microbial
exposures, such as traditional farms, are protected from childhood asthma and atopy. In …