User profiles for Erica Bäckström
Erica BäckströmRIA iMed AstraZeneca Verified email at vigo.se Cited by 379 |
Drug metabolism in the lungs: opportunities for optimising inhaled medicines
Z Enlo-Scott, E Bäckström, I Mudway… - Expert Opinion on Drug …, 2021 - Taylor & Francis
Introduction The lungs possess many xenobiotic metabolizing enzymes which influence the
pharmacokinetics and safety of inhaled medicines. Anticipating metabolism in the lungs …
pharmacokinetics and safety of inhaled medicines. Anticipating metabolism in the lungs …
Mechanisms of inflammatory lung injury in the neonate: lessons from a transgenic mouse model of bronchopulmonary dysplasia
K Bry, A Hogmalm, E Bäckström - Seminars in perinatology, 2010 - Elsevier
The role of inflammation in the pathogenesis of bronchopulmonary dysplasia (BPD) is not
well understood. By using a transgenic mouse expressing the inflammatory cytokine …
well understood. By using a transgenic mouse expressing the inflammatory cytokine …
Development of a novel lung slice methodology for profiling of inhaled compounds
The challenge of defining the concentration of unbound drug at the lung target site after
inhalation limits the possibility to optimize target exposure by compound design. In this study, a …
inhalation limits the possibility to optimize target exposure by compound design. In this study, a …
[HTML][HTML] Developmental stage is a major determinant of lung injury in a murine model of bronchopulmonary dysplasia
E Bäckström, A Hogmalm, U Lappalainen, K Bry - Pediatric research, 2011 - nature.com
Bronchopulmonary dysplasia (BPD) is a common inflammatory lung disease in premature
infants. To study the hypothesis that the sensitivity of the lung to inflammatory injury depends …
infants. To study the hypothesis that the sensitivity of the lung to inflammatory injury depends …
Lung retention by lysosomal trapping of inhaled drugs can be predicted in vitro with lung slices
Modulating and optimizing the local pharmacokinetics of inhaled drugs by chemical design
or formulation is challenged by the lack of predictive in vitro systems and in vivo techniques …
or formulation is challenged by the lack of predictive in vitro systems and in vivo techniques …
Uncovering the regional localization of inhaled salmeterol retention in the lung
Abstract Treatment of respiratory disease with a drug delivered via inhalation is generally
held as being beneficial as it provides direct access to the lung target site with a minimum …
held as being beneficial as it provides direct access to the lung target site with a minimum …
Revealing the regional localization and differential lung retention of inhaled compounds by mass spectrometry imaging
GR Hamm, E Bäckström, M Brülls… - Journal of Aerosol …, 2020 - liebertpub.com
Background: For the treatment of respiratory disease, inhaled drug delivery aims to provide
direct access to pharmacological target sites while minimizing systemic exposure. Despite …
direct access to pharmacological target sites while minimizing systemic exposure. Despite …
[HTML][HTML] Pulmonary metabolism of substrates for key drug-metabolizing enzymes by human alveolar type II cells, human and rat lung microsomes, and the isolated …
Significant pulmonary metabolism of inhaled drugs could have drug safety implications or
influence pharmacological effectiveness. To study this in vitro, lung microsomes or S9 are …
influence pharmacological effectiveness. To study this in vitro, lung microsomes or S9 are …
Role of CXC Chemokine Receptor–2 in a Murine Model of Bronchopulmonary Dysplasia
A Hogmalm, E Bäckström, M Bry… - American Journal of …, 2012 - atsjournals.org
The contribution of neutrophils and CXC chemokines to the pathogenesis of bronchopulmonary
dysplasia is not well defined. The transgenic expression of IL-1β in the pulmonary …
dysplasia is not well defined. The transgenic expression of IL-1β in the pulmonary …
Tissue pharmacokinetics of antisense oligonucleotides
E Bäckström, A Bonetti, P Johnsson, S Öhlin… - … Therapy-Nucleic Acids, 2024 - cell.com
Pharmacokinetics of antisense oligonucleotides (ASO) is characterized by rapid distribution
from plasma to tissue and slow terminal plasma elimination driven by re-distribution from …
from plasma to tissue and slow terminal plasma elimination driven by re-distribution from …