Novel therapies such as type 2 targeting biologics are emerging treatment options for
patients with chronic inflammatory respiratory diseases, fulfilling the needs of severely …

Asthma is a chronic inflammatory airway disease resulting in airflow obstruction, which in
part can become irreversible to conventional therapies, defining the concept of airway …

Interleukin-5 (IL-5) exerts a central pathogenic role in differentiation, recruitment, survival,
and degranulation of eosinophils. Indeed, during the last years, significant advances have …

… Desrosiers MD c , Philippe Gevaert MD, PhD a , Enrico Heffler MD, PhD d e , Claire Hopkins
DM f , Jody R. Tversky MD g , Peter Barker PhD h , David Cohen PhD h , Claire Emson PhD …

NSAID ‐exacerbated respiratory disease (N‐ ERD ) is a chronic eosinophilic, inflammatory
disorder of the respiratory tract occurring in patients with asthma and/or chronic rhinosinusitis …

The review examines recent advances in the biology of eosinophils and how targeting the
interleukin-5 pathway might offer benefit to some patients with severe asthma, EGPA, and …

In less than half a century, allergy, originally perceived as a rare disease, has become a
major public health threat, today affecting the lives of more than 60 million people in Europe, …

Background Clinical characteristics of the international population with severe asthma are
unknown. Intercountry comparisons are hindered by variable data collection within regional …

Severe chronic rhinosinusitis with nasal polyps (CRSwNP) is a debilitating disease with a
significant impact on the quality of life (QoL). It is typically characterized by a type 2 …

Inflammation, structural, and functional abnormalities within the airways are key features of
asthma. Although these processes are well documented, their expression varies across the …