Cerebral blood flow velocities and cerebrovascular resistance in normal‐term neonates in the first 72 hours

DE Forster, E Koumoundouros, V Saxton… - … of paediatrics and …, 2018 - Wiley Online Library
Aim To determine the range of cerebral blood flow velocities ( CBFVs ) and Doppler indices
of cerebrovascular resistance in normal‐term neonates as a baseline for a study of hypoxic‐…

[HTML][HTML] Structural and functional correlations in a large animal model of bleomycin-induced pulmonary fibrosis

L Organ, B Bacci, E Koumoundouros, G Barcham… - BMC pulmonary …, 2015 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a severe and progressive respiratory disease
with poor prognosis. Despite the positive outcomes from recent clinical trials, there is still …

Inhibition of the KCa3.1 Channel Alleviates Established Pulmonary Fibrosis in a Large Animal Model

L Organ, B Bacci, E Koumoundouros… - American Journal of …, 2017 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease of increasing prevalence
marked by poor prognosis and limited treatment options. Ca 2+ -activated K Ca 3.1 …

A novel segmental challenge model for bleomycin-induced pulmonary fibrosis in sheep

L Organ, B Bacci, E Koumoundouros… - Experimental Lung …, 2015 - Taylor & Francis
Background: Idiopathic Pulmonary fibrosis (IPF) is a fatal respiratory disease, characterized
by a progressive fibrosis and worsening lung function. While the outcomes of recent clinical …

[HTML][HTML] KCa3.1 Channel-Blockade Attenuates Airway Pathophysiology in a Sheep Model of Chronic Asthma

…, G Sum, D Barker, E Koumoundouros… - PloS one, 2013 - journals.plos.org
Background The Ca 2+ -activated K + channel K Ca 3.1 is expressed in several structural
and inflammatory airway cell types and is proposed to play an important role in the …

[HTML][HTML] The effects of tumstatin on vascularity, airway inflammation and lung function in an experimental sheep model of chronic asthma

…, GJ Barcham, CL Ugalde, E Koumoundouros… - Scientific Reports, 2016 - nature.com
Tumstatin, a protein fragment of the alpha-3 chain of Collagen IV, is known to be significantly
reduced in the airways of asthmatics. Further, there is evidence that suggests a link …

[HTML][HTML] KCa3.1 channel blockade attenuates microvascular remodelling in a large animal model of bleomycin-induced pulmonary fibrosis

…, KUE Perera, CN Pagel, E Koumoundouros… - Scientific reports, 2019 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with limited
therapeutic options and poor prognosis. IPF has been associated with aberrant vascular …

[HTML][HTML] Tetrathiomolybdate treatment attenuates bleomycin-induced angiogenesis and lung pathology in a sheep model of pulmonary fibrosis

…, SNV Dewage, A Stent, E Koumoundouros… - Frontiers in …, 2021 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a progressive chronic lung disease characterized by
excessive extracellular matrix (ECM) deposition in the parenchyma of the lung. Accompanying …

The efficacy of pirfenidone in a sheep model of pulmonary fibrosis

SNV Dewage, L Organ, E Koumoundouros… - Experimental Lung …, 2019 - Taylor & Francis
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease with unknown
cause. While the drugs nintedanib and pirfenidone have been approved for the treatment …

Chronic airway disease: deteriorating pulmonary function in sheep associated with repeated challenges of house dust mite

E Koumoundouros, RJ Bischof… - Experimental lung …, 2006 - Taylor & Francis
The aim of this work was to characterize lung function and cellular responses in a large
animal model for chronic asthma. All sheep were sensitized to house dust mite (HDM) by …