User profiles for Elias N Ntinginya

Nyanda Elias Ntinginya

National Institute for Medical Research, Mbeya Medical Research Centre
Verified email at nimr-mmrc.org
Cited by 2342

[HTML][HTML] Rapid and Accurate Detection of Mycobacterium tuberculosis in Sputum Samples by Cepheid Xpert MTB/RIF Assay—A Clinical Validation Study

…, G Rojas-Ponce, B Mtafya, K Reither, EN Ntinginya… - PloS one, 2011 - journals.plos.org
Background A crucial impediment to global tuberculosis control is the lack of an accurate,
rapid diagnostic test for detection of patients with active TB. A new, rapid diagnostic method, (…

Increased and expedited case detection by Xpert MTB/RIF assay in childhood tuberculosis: a prospective cohort study

…, B Mtafya, E Michael, EN Ntinginya… - Clinical infectious …, 2012 - academic.oup.com
Background. Diagnosis and timely treatment of tuberculosis in children is hampered by the
absence of fast and reliable tests, especially in the era of human immunodeficiency virus (HIV…

[HTML][HTML] miRNA signatures in sera of patients with active pulmonary tuberculosis

…, D Goletti, A Matteelli, EN Ntinginya, F Aloi, N Heinrich… - PloS one, 2013 - journals.plos.org
Several studies showed that assessing levels of specific circulating microRNAs (miRNAs) is
a non-invasive, rapid, and accurate method for diagnosing diseases or detecting alterations …

Tuberculosis bacillary load, an early marker of disease severity: the utility of tuberculosis molecular bacterial load assay

…, E Kampira, G Davies, N Bhatt, EN Ntinginya… - Thorax, 2020 - thorax.bmj.com
In this comparative biomarker study, we analysed 1768 serial sputum samples from 178
patients at 4 sites in Southeast Africa. We show that tuberculosis Molecular Bacterial Load …

[HTML][HTML] Low sensitivity of a urine LAM-ELISA in the diagnosis of pulmonary tuberculosis

…, I Kroidl, E Saad, JF Huggett, EN Ntinginya… - BMC infectious …, 2009 - Springer
Background The development and evaluation of rapid and accurate new diagnostic tools is
essential to improve tuberculosis (TB) control in developing countries. In a previous study, …

The molecular bacterial load assay replaces solid culture for measuring early bactericidal response to antituberculosis treatment

…, PPJ Phillips, M Hoelscher, EN Ntinginya… - Journal of clinical …, 2014 - Am Soc Microbiol
We evaluated the use of the molecular bacterial load (MBL) assay, for measuring viable
Mycobacterium tuberculosis in sputum, in comparison with solid agar and liquid culture. The …

Performance of urine lipoarabinomannan assays for paediatric tuberculosis in Tanzania

…, B Mtafya, G Rojas-Ponce, EN Ntinginya… - European …, 2015 - Eur Respiratory Soc
We evaluated the diagnostic performance of two tests based on the release of
lipoarabinomannan (LAM) into the urine, the MTB-LAM-ELISA assay and the Determine TB-LAM-strip …

[HTML][HTML] Why being an expert–despite xpert–remains crucial for children in high TB burden settings

…, K Ngo, P Clowes, HR Draper, EN Ntinginya… - BMC infectious …, 2017 - Springer
Background As access to Xpert expands in high TB-burden settings, its performance against
clinically diagnosed TB as a reference standard provides important insight as the majority of …

Rabies mortality and morbidity associated with animal bites in Africa: a case for integrated rabies disease surveillance, prevention and control: a scoping review

…, L Nyakarahuka, GK Helegbe, NE Ntinginya… - BMJ open, 2021 - bmjopen.bmj.com
Objective The objective of this scoping review was to map the current situation and
available evidence and gaps on rabies morbidity, mortality, integrated rabies surveillance …

[HTML][HTML] Burden and associated phenotypic characteristics of tuberculosis infection in adult Africans with diabetes: a systematic review

…, LE Mrema, W Olomi, LT Minja, NE Ntinginya… - Scientific Reports, 2023 - nature.com
Diabetes mellitus (DM) increases the risk of developing tuberculosis infection (TBI). However,
the evidence on the burden and phenotypic characteristics of TBI in African patients with …