A molecular basis for bidirectional communication between the immune and neuroendocrine systems.

JE Blalock - Physiological reviews, 1989 - journals.physiology.org
2 J. EDWIN BLALOCK Vdume 69 systems, which we term neuroimmunoendocrinology(73).
Although this field was, in part, defined in 1977 (13), its origins are much earlier and may …

The syntax of immune-neuroendocrine communication

JE Blalock - Immunology today, 1994 - cell.com
… Here, Edwin Blalock discusses bow these shared ligands and receptors are used as a
common chemical language for communication within and between the immune and …

A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation

…, FS Galin, G Folkerts, FP Nijkamp, JE Blalock - Nature medicine, 2006 - nature.com
We describe the tripeptide neutrophil chemoattractant N-acetyl Pro-Gly-Pro (PGP), derived
from the breakdown of extracellular matrix (ECM), which shares sequence and structural …

Interactions between the neuroendocrine and immune systems: common hormones and receptors.

DA Weigent, JE Blalock - Immunological reviews, 1987 - europepmc.org
The studies reviewed here support a molecular basis for bidirectional communication
between the immune and neuroendocrine systems. The main findings can be summarized as …

Human lymphocyte production of corticotropin and endorphin-like substances: association with leukocyte interferon.

EM Smith, JE Blalock - … of the National Academy of Sciences, 1981 - National Acad Sciences
Human leukocyte interferon (hIFN-alpha) preparations contain immunologically and
biologically recognizable endorphin and corticotropin-like (ACTH-like) activities. The ACTH …

A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation

…, SM Rowe, JP Clancy, JE Blalock - The Journal of …, 2008 - journals.aai.org
Chronic neutrophilic inflammation is a manifestation of a variety of lung diseases including
cystic fibrosis (CF). There is increasing evidence that fragments of extracellular matrix proteins…

[PDF][PDF] Activated PMN exosomes: pathogenic entities causing matrix destruction and disease in the lung

…, MT Dransfield, R Tirouvanziam, A Gaggar, JE Blalock - Cell, 2019 - cell.com
Here, we describe a novel pathogenic entity, the activated PMN (polymorphonuclear leukocyte,
ie, neutrophil)-derived exosome. These CD63 + /CD66b + nanovesicles acquire surface-…

A Critical Role for LTA4H in Limiting Chronic Pulmonary Neutrophilic Inflammation

…, S Shastry, SM Rowe, YM Shim, T Hussell, JE Blalock - Science, 2010 - science.org
Leukotriene A 4 hydrolase (LTA 4 H) is a proinflammatory enzyme that generates the
inflammatory mediator leukotriene B 4 (LTB 4 ). LTA 4 H also possesses aminopeptidase activity …

[HTML][HTML] MMP generated matrikines

JM Wells, A Gaggar, JE Blalock - Matrix biology, 2015 - Elsevier
Matrikines originate from the fragmentation of extracellular matrix proteins and regulate cellular
activities by interacting with specific receptors. Matrikines are implicated in inflammation, …

Human leukocyte interferon: structural and biological relatedness to adrenocorticotropic hormone and endorphins.

JE Blalock, EM Smith - … of the National Academy of Sciences, 1980 - National Acad Sciences
Anti-alpha-corticotropin [anti-ACTH alpha (1-13)](also alpha-melanotropin) and anti-gamma-endorphin
antisera neutralized human leukocyte interferon activity but not fibroblast …