The cytokine IL-6 acts via a specific receptor complex that consists of the membrane-bound
IL-6 receptor (mIL-6R) or the soluble IL-6 receptor (sIL-6R) and glycoprotein 130 (gp130). In …

Cyclo‐oxygenase (COX) is the enzyme that converts arachidonic acid to prostaglandin H 2 (PGH
2 ) which can then be further metabolized to prostanoids which modulate various …

Tiotropium bromide (Ba 679 BR) is a novel potent and long-lasting muscarinic antagonist
that has been developed for the treatment of chronic obstructive airways disease (COPD). …

Type 2 immunity evolved to combat helminth infections by orchestrating a combined
protective response of innate and adaptive immune cells and promotion of parasitic worm …

Eotaxin is a novel C‐C chemokine with selective chemoattractant activity for eosinophils.
We determined whether eotaxin could be produced by human airway smooth muscle (HASM) …

Ba 679 BR [7(S)-(1 alpha, 2 beta, 4 beta, 5 alpha, 7 beta)-7-[(hydroxydi(2-thienyl) acetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0(2,4)]nonan
e bromide] is a new long-acting …

In this study we have evaluated the pharmacological profile of the muscarinic antagonist
glycopyrrolate in guinea‐pig and human airways in comparison with the commonly used …

The nerve growth factor (NGF) receptor TrkA is widely expressed in non-neural tissues
suggesting pleiotropic functions outside the nervous system. Based on pharmacological and …

We investigated the effect of the p38 kinase inhibitor SB 203580 on airway inflammation
induced by aerosolized lipopolysaccharide (LPS) in male Wistar rats. SB 203580 significantly …

We postulated that the seleno-organic compound ebselen would attenuate neutrophil recruitment
and activation after aerosolized challenge with endotoxin (LPS) through its effect as an …