Community-acquired pneumonia causes great mortality and morbidity and high costs worldwide.
Empirical selection of antibiotic treatment is the cornerstone of management of patients …

Leishmania are protozoan parasites that, as amastigotes, live in the macrophages of mammalian
hosts within compartments called parasitophorous vacuoles. These organelles share …

The state of antileishmanial chemotherapy is strongly compromised by the emergence of
drug-resistant Leishmania. The evolution of drug-resistant phenotypes has been linked to the …

… Phosphatases, sulfatases (4), and various proteases of host cell origin (E. Prina, J.-C. Antoine,
B. … The same cell at two different foci is shown in panels E and F. Bars represent 10 ,um. …

… , OTR, and AT; analysis and interpretation of the data—E. Prina, OTR, and AT;
recruitment of patients and data collection—E. Polverino and CC; drafting the manuscript—…

Leishmania spp. are intracellular protozoan parasites that cause a wide spectrum of diseases
in humans and dogs worldwide. However, monitoring of the Leishmania burden in its …

Rationale: The Sepsis-3 Task Force updated the clinical criteria for sepsis, excluding the
need for systemic inflammatory response syndrome (SIRS) criteria. The clinical implications of …

We report the synthesis of substituted quinolines and their in vitro biological evaluation
against the causal agents of cutaneous leishmaniasis, visceral leishmaniasis, African …

Protozoan parasites Leishmania alternate between a flagellated promastigote form and an
amastigote form. In their mammalian hosts, Leishmania survive and multiply in macrophages. …

… Axillary body temperature was obtained by electronic thermometer. A blinded radiologist
interpreted the CXR. CXRs were reviewed after the trial to confirm inclusion criteria. …