Lung capillaries, best known for vital gas exchange, also contribute to neutrophil margination,
a phenomenon resulting in large numbers of pulmonary vascular neutrophils. Importantly, …

Many bacteria use the second messenger cyclic diguanylate (c-di-GMP) to control motility,
biofilm production and virulence. Here, we identify a thermosensory diguanylate cyclase (TdcA…

Rationale: Vascular remodeling in pulmonary arterial hypertension (PAH) results from
smooth muscle cell hypertrophy and proliferation of vascular cells. Loss of BMPR-II (bone …

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with an unknown cause. Two
drugs, nintedanib and pirfenidone, have been shown to slow, but not stop, disease progression…

Pulmonary arterial hypertension (PAH) is a vascular disease characterized by persistent
precapillary pulmonary hypertension (PH), leading to progressive right heart failure and …

Pulmonary innate immunity is required for host defense; however, excessive neutrophil
inflammation can cause life-threatening acute lung injury. B lymphocytes can be regulatory, yet …

Infections of the lung cause observable sickness thought to be secondary to inflammation.
Signs of sickness are crucial to alert others via behavioral-immune responses to limit contact …

Solid cancers are spatially and temporally heterogeneous. This limits the use of invasive
biopsy based molecular assays but gives huge potential for medical imaging, which has the …

The demands on a pulmonary arterial hypertension (PAH) treatment algorithm are multiple
and in some ways conflicting. The treatment algorithm usually includes different types of …

This study was undertaken to characterize the molecular and pathological mechanisms of
pulmonary vascular remodeling in a patient who developed chronic lung allograft dysfunction …