Mitochondria play a central role in both apoptosis and necrosis through the opening of the
mitochondrial permeability transition pore (MPTP). This is thought to be formed through a Ca 2…

The complete nucleotide sequence of two human T-cell leukaemia type III (HTLV-III) proviral
DNAs each have four long open reading frames, the first two corresponding to the gag and …

Although metformin is widely used for the treatment of non-insulin-dependent diabetes, its
mode of action remains unclear. Here we provide evidence that its primary site of action is …

… Lott IT, Head E. Alzheimer disease and Down syndrome: factors in pathogenesis. Neurobiol
… [53] Lott IT, Head E. Down syndrome and Alzheimer's disease: A link between development …

Adults with Down syndrome (DS) develop Alzheimer disease (AD) pathology progressively
with age but clinical signs of dementia are delayed by at least 10 years after the first signs of …

Down syndrome (DS), or trisomy 21, is a common disorder associated with several complex
clinical phenotypes. Although several hypotheses have been put forward, it is unclear as to …

The VLT-FLAMES Tarantula Survey (VFTS) is an ESO Large Programme that has obtained
multi-epoch optical spectroscopy of over 800 massive stars in the 30 Doradus region of the …

… (E) Median levels of serum periostin were highest in T H 17-high versus T H 2-high and T
H … (E and F) IL-13 (E) and IL-17 (F) production was measured by gene expression and in …

BACKGROUND: Thymic stromal lymphopoietin (TSLP) is a cytokine implicated in the
pathophysiology of asthma through 2 distinct pathways: a TSLP–OX40 ligand (OX40L)–T cell axis …

Background Late-stage isolated medial knee osteoarthritis can be treated with total knee
replacement (TKR) or partial knee replacement (PKR). There is high variation in treatment …