Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
…, CH Compton, H Bisgaard, E Bucchioni… - European …, 2015 - Eur Respiratory Soc
U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical
companies and six patient organisations with the objective of improving the understanding …
companies and six patient organisations with the objective of improving the understanding …
[HTML][HTML] High levels of interleukin-6 in the exhaled breath condensate of patients with COPD
E Bucchioni, SA Kharitonov, L Allegra, PJ Barnes - Respiratory medicine, 2003 - Elsevier
Background: Chronic obstructive pulmonary disease (COPD) is characterised by chronic
inflammation of the respiratory tract. Methods: We investigated the presence of interleukin-6 (IL-…
inflammation of the respiratory tract. Methods: We investigated the presence of interleukin-6 (IL-…
[HTML][HTML] Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation
…, J Brandsma, P Brinkman, E Bucchioni… - Journal of allergy and …, 2019 - Elsevier
Background Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R)
to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in …
to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in …
INSTEAD: a randomised switch trial of indacaterol versus salmeterol/fluticasone in moderate COPD
…, D Young, R Cameron, E Bucchioni… - European …, 2014 - Eur Respiratory Soc
The Indacaterol: Switching Non-exacerbating Patients with Moderate COPD From
Salmeterol/Fluticasone to Indacaterol (INSTEAD) study investigated the effect of switching patients at …
Salmeterol/Fluticasone to Indacaterol (INSTEAD) study investigated the effect of switching patients at …
Pathway discovery using transcriptomic profiles in adult-onset severe asthma
…, J Brandsma, P Brinkman, E Bucchioni… - Journal of Allergy and …, 2018 - Elsevier
Background Adult-onset severe asthma is characterized by highly symptomatic disease
despite high-intensity asthma treatments. Understanding of the underlying pathways of this …
despite high-intensity asthma treatments. Understanding of the underlying pathways of this …
[HTML][HTML] Italian real-life experience of omalizumab
…, PL Di Napoli, R Maselli, G Pelaia, E Bucchioni… - Respiratory …, 2010 - Elsevier
Omalizumab is a humanized murine monoclonal antibody directed toward a portion of the
IgE indicated in Europe for the treatment of severe persistent allergic asthma, inadequately …
IgE indicated in Europe for the treatment of severe persistent allergic asthma, inadequately …
IL-17–high asthma with features of a psoriasis immunophenotype
…, J Brandsma, P Brinkman, E Bucchioni… - Journal of Allergy and …, 2019 - Elsevier
… DEGs (q = 3.6E-04, Table II), which is supported by disease and function enrichment
analysis, identifying 79 genes previously implicated in patients with psoriasis (P = 5.32E-17, see …
analysis, identifying 79 genes previously implicated in patients with psoriasis (P = 5.32E-17, see …
[HTML][HTML] The Novartis view on emerging drugs and novel targets for the treatment of chronic obstructive pulmonary disease
C Compton, D McBryan, E Bucchioni… - Pulmonary Pharmacology …, 2013 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a debilitating lung disease characterized
by airflow limitation and chronic inflammation in the lungs. The mainstay of drug therapy for …
by airflow limitation and chronic inflammation in the lungs. The mainstay of drug therapy for …
[PDF][PDF] Treating moderate-to-severe allergic asthma with anti-IgE monoclonal antibody (omalizumab). An update
G D'Amato, M Perticone, E Bucchioni… - Eur Ann Allergy Clin …, 2010 - eurannallergyimm.com
Increased asthma severity is not only associated with enhanced recurrent hospitalisation and
mortality but also with higher social costs. Most cases of asthma are atopic in nature, with …
mortality but also with higher social costs. Most cases of asthma are atopic in nature, with …
[HTML][HTML] Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status
…, J Brandsma, P Brinkman, E Bucchioni… - Respiratory …, 2020 - Elsevier
Background Asthma prevalence is 339 million globally. ‘Severe asthma’ (SA) comprises
subjects with uncontrolled asthma despite proper management. Objectives To compare asthma …
subjects with uncontrolled asthma despite proper management. Objectives To compare asthma …