Extracellular vesicles (EVs) are a family of particles/vesicles present in blood and body fluids,
composed of phospholipid bilayers that carry a variety of molecules that can mediate cell …

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

Rationale: Airway remodeling and inflammation are characteristic features of adult asthma
that are still poorly investigated in childhood asthma. Objectives: To examine epithelial and …

Inflammation, oxidative stress and apoptosis, which are involved in chronic obstructive
pulmonary disease (COPD) pathogenesis, may activate the p38 subgroup of mitogen-activated …

… Weakly positive alveolar macrophages (arrows) can be observed in the (E) smoking
subject and (F) nonsmoking control subject. Original magnification = ×200 (bottom insert: ×400). …

From the discovery that alpha-1 antitrypsin (AAT) was an effective inhibitor of neutrophil
elastase originated the classic paradigm of protease/antiprotease imbalance, linking lung …

Airway pathology has been extensively investigated in adulthood asthma, whereas only few
studies examined bronchial biopsies in childhood asthma. To evaluate the airway pathology …

Rationale: Epidemiologic studies have shown that, in atopic children, wheezing is more likely
to persist into adulthood, eventually becoming asthma, whereas it appears to resolve by …

BACKGROUND: Impaired immune response to viral infections in atopic asthmatic patients
has been recently reported and debated. Whether this condition is present in childhood and …

… factors as: (33) A = ( m r e f r + n r e f s ) d x r e f + x r e f 2 [ h ( ( ( 1 − β ) 1 − β ζ r e f + 1 ) 2 n r
… e ( d 1 − 2 s d h x r e f 2 ) 2 − b e ( d 1 − 2 s d h x r e f 2 ) + c e . (35) C = ( W m 1 − 2 s d h x r e …