[HTML][HTML] Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models
The application of multiple omics technologies in biomedical cohorts has the potential to reveal
patient-level disease characteristics and individualized response to treatment. However, …
patient-level disease characteristics and individualized response to treatment. However, …
[PDF][PDF] Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study
The presentation and underlying pathophysiology of type 2 diabetes (T2D) is complex and
heterogeneous. Recent studies attempted to stratify T2D into distinct subgroups using data-…
heterogeneous. Recent studies attempted to stratify T2D into distinct subgroups using data-…
[HTML][HTML] Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts
Background Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious
health complications in individuals with and without type 2 diabetes (T2D). Early diagnosis …
health complications in individuals with and without type 2 diabetes (T2D). Early diagnosis …
[HTML][HTML] Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits
We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites
derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, …
derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, …
The effect of pulmonary rehabilitation on healthcare utilization in chronic obstructive pulmonary disease: the Northeast Pulmonary Rehabilitation Consortium
…, M Haggerty, L Hovey, D McEvoy… - Journal of …, 2006 - journals.lww.com
Pulmonary rehabilitation has become a standard of care for patients with chronic lung disease
such as chronic obstructive pulmonary disease (COPD) who remain symptomatic or have …
such as chronic obstructive pulmonary disease (COPD) who remain symptomatic or have …
Processes underlying glycemic deterioration in type 2 diabetes: an IMI DIRECT study
…, J Kaye, AT Hattersley, A Heggie, D McEvoy… - Diabetes …, 2021 - Am Diabetes Assoc
OBJECTIVE We investigated the processes underlying glycemic deterioration in type 2 diabetes
(T2D). RESEARCH DESIGN AND METHODS A total of 732 recently diagnosed patients …
(T2D). RESEARCH DESIGN AND METHODS A total of 732 recently diagnosed patients …
[HTML][HTML] Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration
…, H Deshmukh, A Heggie, D Wake, D McEvoy… - Journal of …, 2019 - Elsevier
Background & Aims Excess liver iron content is common and is linked to the risk of hepatic
and extrahepatic diseases. We aimed to identify genetic variants influencing liver iron content …
and extrahepatic diseases. We aimed to identify genetic variants influencing liver iron content …
[HTML][HTML] Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study
Background The rising prevalence of type 2 diabetes (T2D) poses a major global challenge.
It remains unresolved to what extent transcriptomic signatures of metabolic dysregulation …
It remains unresolved to what extent transcriptomic signatures of metabolic dysregulation …
Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study
Genetic variants identified by genome-wide association studies can contribute to disease
risk by altering the production and abundance of mRNA, proteins and other molecules. …
risk by altering the production and abundance of mRNA, proteins and other molecules. …
Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models
… Donna McEvoy … Donna McEvoy & Ian McVittie … Donna McEvoy …