OBJECTIVES: This study compared the efficacy of a tetrahydrocannabinol:cannabidiol (THC:CBD)
extract, a nonopioid analgesic endocannabinoid system modulator, and a THC extract…

Purpose: Brain metastases develop in one third of patients with advanced HER2+ breast
cancer. Effective therapy for patients with central nervous system (CNS) progression after …

Context Chronic pain in patients with advanced cancer poses a serious clinical challenge.
The Δ9-tetrahydrocannabinol (THC)/cannabidiol (CBD) oromucosal spray (US Adopted Name…

Steroids are widely used in oncology and have been demonstrated to possess an anticancer
effect or antiswelling effect. They are considered to improve refractory symptoms such as …

PURPOSE This phase I study of Taxotere (RP 56976, NSC 628503; docetaxel, Rhône-Poulenc
Rorer, Antony, France) was undertaken to determine the maximum-tolerated dose (MTD)…

Goals and work Despite medical awareness, intractable pain is a serious problem in cancer
and occurs in up to 2% of advanced cancer patients. However, few data are available …

The occurrence of undesirable side effects due to opioids (delirium, confusion, myoclonus,
nausea, emesis) is one of the major complications in the management of pain, especially in …

Due to improvements in diagnosis and systemic therapy, brain metastases are an increasingly
common cause of morbidity and mortality for patients with advanced breast cancer. The …

Goals of the work: This open compassionate-use prospective registration study evaluated
the tolerability, ease of use and applied doses of transdermal (TTS) fentanyl in adult patients …

Supportive care in cancer has become a paradigm for the treatment in oncology. Now, we
have guidelines and active research in that field, making this area of clinical oncology both …