Bacteriophages Can Treat and Prevent Pseudomonas aeruginosa Lung Infections

L Debarbieux, D Leduc, D Maura… - The Journal of …, 2010 - academic.oup.com
Antibiotic-resistant bacteria threaten life worldwide. Although new antibiotics are scarce, the
use of bacteriophages, viruses that infect bacteria, is rarely proposed as a means of …

Turnover of CD4+ and CD8+ T Lymphocytes in HIV-1 Infection as Measured by Ki-67 Antigen

…, S Yerly, GA Schockmel, D Leduc… - The Journal of …, 1998 - rupress.org
We investigated CD4 + and CD8 + T cell turnover in both healthy and HIV-1–infected adults
by measuring the nuclear antigen Ki-67 specific for cell proliferation. The mean growth …

[HTML][HTML] Leukocyte elastase negatively regulates stromal cell-derived factor-1 (SDF-1)/CXCR4 binding and functions by amino-terminal processing of SDF-1 and …

…, F Baleux, I Staropoli, K Le-Barillec, D Leduc… - Journal of Biological …, 2002 - ASBMB
Activation of CXCR4 by the CXC chemokine stromal cell-derived factor-1 (SDF-1) requires
interaction of the amino-terminal domains of both molecules. We report that proteinases …

Pseudomonas aeruginosa Elastase Disables Proteinase-Activated Receptor 2 in Respiratory Epithelial Cells

S Dulon, D Leduc, GS Cottrell, J D'Alayer… - American journal of …, 2005 - atsjournals.org
Pseudomonas aeruginosa, a major lung pathogen in cystic fibrosis (CF) patients, secretes
an elastolytic metalloproteinase (EPa) contributing to bacterial pathogenicity. Proteinase-…

A prospective trial of structured treatment interruptions in human immunodeficiency virus infection

…, A Telenti, R Weber, D Leduc… - Archives of internal …, 2003 - jamanetwork.com
Background According to the "autovaccination hypothesis," reexposure to human
immunodeficiency virus (HIV) during treatment interruptions may stimulate the HIV-specific immune …

[HTML][HTML] Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity

…, I Sermet-Gaudelus, D Sands, D Leduc… - Nature …, 2014 - nature.com
Young cystic fibrosis (CF) patients’ airways are mainly colonized by Staphylococcus aureus,
while Pseudomonas aeruginosa predominates in adults. However, the mechanisms behind …

[HTML][HTML] Concrete crack monitoring using a novel strain transfer model for distributed fiber optics sensors

A Bassil, X Chapeleau, D Leduc, O Abraham - Sensors, 2020 - mdpi.com
In this paper, we study the strain transfer mechanism between a host material and an optical
fiber. A new analytical model handling imperfect bonding between layers is proposed. A …

Proteolytic regulation of the urokinase receptor/CD87 on monocytic cells by neutrophil elastase and cathepsin G

N Beaufort, D Leduc, JC Rousselle… - The Journal of …, 2004 - journals.aai.org
The urokinase receptor (CD87) participates to the pericellular proteolytic potential of
migrating cells and to the recruitment of leukocytes during inflammation. It consists of three …

The Pseudomonas aeruginosa LasB Metalloproteinase Regulates the Human Urokinase-Type Plasminogen Activator Receptor through Domain-Specific …

D Leduc, N Beaufort, S de Bentzmann… - Infection and …, 2007 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic pathogen in human lungs, where its secretable
LasB metalloproteinase can be a virulence factor. The urokinase-type plasminogen …

[HTML][HTML] Distributed fiber optics sensing and coda wave interferometry techniques for damage monitoring in concrete structures

…, E Niederleithinger, O Abraham, D Leduc - Sensors, 2019 - mdpi.com
The assessment of Coda Wave Interferometry (CWI) and Distributed Fiber Optics Sensing (DFOS)
techniques for the detection of damages in a laboratory size reinforced concrete beam …