Rationale: Heterogeneity in asthma expression is multidimensional, including variability in
clinical, physiologic, and pathologic parameters. Classification requires consideration of …

Background Asthma is a heterogeneous disease in which there is a differential response to
asthma treatments. This heterogeneity needs to be evaluated so that a personalized …

Type-2 (T2) immune responses in airway epithelial cells (AECs) classifies mild–moderate
asthma into a T2-high phenotype. We examined whether currently available clinical …

Background Asthma treatment guidelines recommend increasing corticosteroid dose to
control symptoms and reduce exacerbations. This approach is potentially flawed because …

Background Severe asthma is a heterogeneous condition, as shown by independent cluster
analyses based on demographic, clinical, and inflammatory characteristics. A next step is to …

Severe asthma patients with a significant smoking history have airflow obstruction with
reported neutrophilia. We hypothesise that multi-omic analysis will enable the definition of …

Background Studies in the USA and Canada have reported increasing or stable rates of
hospital admissions for hypoglycaemia. Some data from small studies are available for other …

Background. We examined the effect of a second interviewer's demeanour on cues to
deception. We predicted that a supportive demeanour would be the most beneficial for eliciting …

Airway remodelling describes the histopathological changes leading to fixed airway
obstruction in patients with asthma and includes extra-cellular matrix (ECM) deposition. Matrix …

… Dr Shaw has received speaker fees from Chiesi and Astra Zeneca and advisory board fees
from Adherium, Nuvoair, Astra Zeneca and Chiesi. Dr Loza is employed by and own stock in …