Pulmonary hypertension (PH) is a pathophysiological disorder that may involve multiple
clinical conditions and may be associated with a variety of cardiovascular and respiratory …

This document provides clinical recommendations for the management of severe asthma.
Comprehensive evidence syntheses, including meta-analyses, were performed to summarise …

Guidelines summarize and evaluate available evidence, with the aim of assisting health
professionals in proposing the best management strategies for an individual patient with a given …

Objectives Mammography screening is generally accepted in women aged 50–69, but the
balance between benefits and harms remains controversial in other age groups. This study …

Cities are constantly transforming and, consequently, attracting efforts from researchers and
opportunities to the industry. New transportation systems are being built in order to meet …

Background Airway inflammation in asthma involves innate immune responses. Toll‐like
receptors ( TLR s) and thymic stromal lymphopoietin ( TSLP ) are thought to be involved in …

Recent clinical trials of as-needed fixed-dose combination of inhaled corticosteroid (ICS)/formoterol
have provided new evidence that may warrant a reconsideration of current practice. …

The cytokine-like hormone leptin is known to exert important functions on the modulation of
immune responses. Some of these effects are dependent on the property of leptin to …

Asthma often remains uncontrolled, despite the fact that the pharmacological treatment has
undergone large changes. We studied changes in the treatment of asthma over a 20-year …

Background Fractional exhaled nitric oxide (FeNO) is a marker of type-2 inflammation used
both to support diagnosis of asthma and follow up asthma patients. The associations of …