A deletion in the bovine myostatin gene causes the double–muscled phenotype in cattle
L Grobet, LJ Royo Martin, D Poncelet, D Pirottin… - Nature …, 1997 - nature.com
An exceptional muscle development commonly referred to as ‘double-muscled’ (Fig. 1) has
been seen in several cattle breeds and has attracted considerable attention from beef …
been seen in several cattle breeds and has attracted considerable attention from beef …
A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep
A Clop, F Marcq, H Takeda, D Pirottin, X Tordoir… - Nature …, 2006 - nature.com
Texel sheep are renowned for their exceptional meatiness. To identify the genes underlying
this economically important feature, we performed a whole-genome scan in a Romanov × …
this economically important feature, we performed a whole-genome scan in a Romanov × …
Molecular definition of an allelic series of mutations disrupting the myostatin function and causing double-muscling in cattle
…, D Poncelet, LJ Royo, B Brouwers, D Pirottin… - Mammalian …, 1998 - Springer
We have determined the entire myostatin coding sequence for 32 double-muscled cattle
sampled from ten European cattle breeds. Seven DNA sequence polymorphisms were identified…
sampled from ten European cattle breeds. Seven DNA sequence polymorphisms were identified…
[HTML][HTML] Lung-resident eosinophils represent a distinct regulatory eosinophil subset
…, X Xiao, MA Birrell, D Pirottin… - The Journal of …, 2016 - Am Soc Clin Investig
Increases in eosinophil numbers are associated with infection and allergic diseases, including
asthma, but there is also evidence that eosinophils contribute to homeostatic immune …
asthma, but there is also evidence that eosinophils contribute to homeostatic immune …
[HTML][HTML] MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation
Resident tissue macrophages (RTMs) are differentiated immune cells that populate distinct
niches and exert important tissue-supportive functions. RTM maintenance is thought to rely …
niches and exert important tissue-supportive functions. RTM maintenance is thought to rely …
[HTML][HTML] Non-classical tissue monocytes and two functionally distinct populations of interstitial macrophages populate the mouse lung
Resident tissue macrophages (RTM) can fulfill various tasks during development, homeostasis,
inflammation and repair. In the lung, non-alveolar RTM, called interstitial macrophages (…
inflammation and repair. In the lung, non-alveolar RTM, called interstitial macrophages (…
[PDF][PDF] Exposure to bacterial CpG DNA protects from airway allergic inflammation by expanding regulatory lung interstitial macrophages
…, C Fernandes, S Olivier, M Toussaint, D Pirottin… - Immunity, 2017 - cell.com
Living in a microbe-rich environment reduces the risk of developing asthma. Exposure of
humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces these protective …
humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces these protective …
Modulating skeletal muscle mass by postnatal, muscle‐specific inactivation of the myostatin gene
By using a conditional gene targeting approach exploiting the cre‐lox system, we show that
postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a …
postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a …
Airway macrophages encompass transcriptionally and functionally distinct subsets altered by smoking
M Liégeois, Q Bai, L Fievez, D Pirottin… - American Journal of …, 2022 - atsjournals.org
Alveolar macrophages (AMs) are functionally important innate cells involved in lung
homeostasis and immunity and whose diversity in health and disease is a subject of intense …
homeostasis and immunity and whose diversity in health and disease is a subject of intense …
[HTML][HTML] Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation
…, N Stakenborg, L van Baarle, Q Wu, D Pirottin… - Mucosal …, 2022 - Elsevier
Monocyte-derived macrophages (Mϕs) are crucial regulators during muscularis inflammation.
However, it is unclear which micro-environmental factors are responsible for monocyte …
However, it is unclear which micro-environmental factors are responsible for monocyte …