A deletion in the bovine myostatin gene causes the double–muscled phenotype in cattle

L Grobet, LJ Royo Martin, D Poncelet, D Pirottin… - Nature …, 1997 - nature.com
An exceptional muscle development commonly referred to as ‘double-muscled’ (Fig. 1) has
been seen in several cattle breeds and has attracted considerable attention from beef …

A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep

A Clop, F Marcq, H Takeda, D Pirottin, X Tordoir… - Nature …, 2006 - nature.com
Texel sheep are renowned for their exceptional meatiness. To identify the genes underlying
this economically important feature, we performed a whole-genome scan in a Romanov × …

Molecular definition of an allelic series of mutations disrupting the myostatin function and causing double-muscling in cattle

…, D Poncelet, LJ Royo, B Brouwers, D Pirottin… - Mammalian …, 1998 - Springer
We have determined the entire myostatin coding sequence for 32 double-muscled cattle
sampled from ten European cattle breeds. Seven DNA sequence polymorphisms were identified…

[HTML][HTML] Lung-resident eosinophils represent a distinct regulatory eosinophil subset

…, X Xiao, MA Birrell, D Pirottin… - The Journal of …, 2016 - Am Soc Clin Investig
Increases in eosinophil numbers are associated with infection and allergic diseases, including
asthma, but there is also evidence that eosinophils contribute to homeostatic immune …

[HTML][HTML] MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation

D Vanneste, Q Bai, S Hasan, W Peng, D Pirottin… - Nature …, 2023 - nature.com
Resident tissue macrophages (RTMs) are differentiated immune cells that populate distinct
niches and exert important tissue-supportive functions. RTM maintenance is thought to rely …

[HTML][HTML] Non-classical tissue monocytes and two functionally distinct populations of interstitial macrophages populate the mouse lung

…, S De Schepper, S Chakarov, F Farnir, D Pirottin… - Nature …, 2019 - nature.com
Resident tissue macrophages (RTM) can fulfill various tasks during development, homeostasis,
inflammation and repair. In the lung, non-alveolar RTM, called interstitial macrophages (…

[PDF][PDF] Exposure to bacterial CpG DNA protects from airway allergic inflammation by expanding regulatory lung interstitial macrophages

…, C Fernandes, S Olivier, M Toussaint, D Pirottin… - Immunity, 2017 - cell.com
Living in a microbe-rich environment reduces the risk of developing asthma. Exposure of
humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces these protective …

Modulating skeletal muscle mass by postnatal, muscle‐specific inactivation of the myostatin gene

L Grobet, D Pirottin, F Farnir, D Poncelet, LJ Royo… - genesis, 2003 - Wiley Online Library
By using a conditional gene targeting approach exploiting the cre‐lox system, we show that
postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a …

Airway macrophages encompass transcriptionally and functionally distinct subsets altered by smoking

M Liégeois, Q Bai, L Fievez, D Pirottin… - American Journal of …, 2022 - atsjournals.org
Alveolar macrophages (AMs) are functionally important innate cells involved in lung
homeostasis and immunity and whose diversity in health and disease is a subject of intense …

[HTML][HTML] Enteric glial cells favor accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

…, N Stakenborg, L van Baarle, Q Wu, D Pirottin… - Mucosal …, 2022 - Elsevier
Monocyte-derived macrophages (Mϕs) are crucial regulators during muscularis inflammation.
However, it is unclear which micro-environmental factors are responsible for monocyte …