User profiles for Dietmar Rieder

Dietmar Rieder

Institute of Bioinformatics, Medical University of Innsbruck
Verified email at i-med.ac.at
Cited by 6967

[PDF][PDF] Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade

…, M Angelova, C Mayer, M Efremova, D Rieder… - Cell reports, 2017 - cell.com
The Cancer Genome Atlas revealed the genomic landscapes of human cancers. In parallel,
immunotherapy is transforming the treatment of advanced cancers. Unfortunately, the …

[HTML][HTML] Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data

…, C Mayer, C Plattner, G Laschober, D Rieder… - Genome medicine, 2019 - Springer
We introduce quanTIseq, a method to quantify the fractions of ten immune cell types from bulk
RNA-sequencing data. quanTIseq was extensively validated in blood and tumor samples …

[HTML][HTML] Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial

…, R Helbok, H Prosch, D Rieder… - European …, 2021 - Eur Respiratory Soc
Background After the 2002/2003 severe acute respiratory syndrome outbreak, 30% of
survivors exhibited persisting structural pulmonary abnormalities. The long-term pulmonary …

[PDF][PDF] High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer

…, M Sykora, F Augustin, K Schmitz, F Finotello, D Rieder… - Cancer cell, 2022 - cell.com
Non-small cell lung cancer (NSCLC) is characterized by molecular heterogeneity with
diverse immune cell infiltration patterns, which has been linked to therapy sensitivity and …

[HTML][HTML] Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution

M Efremova, D Rieder, V Klepsch… - Nature …, 2018 - nature.com
The cancer immunoediting hypothesis postulates a dual role of the immune system: protecting
the host by eliminating tumor cells, and shaping the tumor by editing its genome. Here, we …

[HTML][HTML] Distinct 5-methylcytosine profiles in poly (A) RNA from mouse embryonic stem cells and brain

T Amort, D Rieder, A Wille, D Khokhlova-Cubberley… - Genome biology, 2017 - Springer
Background Recent work has identified and mapped a range of posttranscriptional
modifications in mRNA, including methylation of the N6 and N1 positions in adenine, …

[HTML][HTML] Neoantigens generated by individual mutations and their role in cancer immunity and immunotherapy

M Efremova, F Finotello, D Rieder… - Frontiers in …, 2017 - frontiersin.org
Recent preclinical and clinical studies have proved the long-standing hypothesis that tumors
elicit adaptive immune responses and that the antigens driving effective T-cell response are …

Scirpy: a Scanpy extension for analyzing single-cell T-cell receptor-sequencing data

G Sturm, T Szabo, G Fotakis, M Haider, D Rieder… - …, 2020 - academic.oup.com
Advances in single-cell technologies have enabled the investigation of T-cell phenotypes
and repertoires at unprecedented resolution and scale. Bioinformatic methods for the efficient …

Deconvoluting tumor-infiltrating immune cells from RNA-seq data using quanTIseq

C Plattner, F Finotello, D Rieder - Methods in enzymology, 2020 - Elsevier
Tumor-infiltrating immune cells comprise various cells of the innate and the adaptive immune
system, which influence tumor growth and response to immunotherapy by exerting anti- …

Next-generation computational tools for interrogating cancer immunity

F Finotello, D Rieder, H Hackl, Z Trajanoski - Nature Reviews Genetics, 2019 - nature.com
The remarkable success of cancer therapies with immune checkpoint blockers is
revolutionizing oncology and has sparked intensive basic and translational research into the …