User profiles for Dietmar Rieder
Dietmar RiederInstitute of Bioinformatics, Medical University of Innsbruck Verified email at i-med.ac.at Cited by 6967 |
[PDF][PDF] Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade
The Cancer Genome Atlas revealed the genomic landscapes of human cancers. In parallel,
immunotherapy is transforming the treatment of advanced cancers. Unfortunately, the …
immunotherapy is transforming the treatment of advanced cancers. Unfortunately, the …
[HTML][HTML] Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data
…, C Mayer, C Plattner, G Laschober, D Rieder… - Genome medicine, 2019 - Springer
We introduce quanTIseq, a method to quantify the fractions of ten immune cell types from bulk
RNA-sequencing data. quanTIseq was extensively validated in blood and tumor samples …
RNA-sequencing data. quanTIseq was extensively validated in blood and tumor samples …
[HTML][HTML] Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial
Background After the 2002/2003 severe acute respiratory syndrome outbreak, 30% of
survivors exhibited persisting structural pulmonary abnormalities. The long-term pulmonary …
survivors exhibited persisting structural pulmonary abnormalities. The long-term pulmonary …
[PDF][PDF] High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer
…, M Sykora, F Augustin, K Schmitz, F Finotello, D Rieder… - Cancer cell, 2022 - cell.com
Non-small cell lung cancer (NSCLC) is characterized by molecular heterogeneity with
diverse immune cell infiltration patterns, which has been linked to therapy sensitivity and …
diverse immune cell infiltration patterns, which has been linked to therapy sensitivity and …
[HTML][HTML] Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution
The cancer immunoediting hypothesis postulates a dual role of the immune system: protecting
the host by eliminating tumor cells, and shaping the tumor by editing its genome. Here, we …
the host by eliminating tumor cells, and shaping the tumor by editing its genome. Here, we …
[HTML][HTML] Distinct 5-methylcytosine profiles in poly (A) RNA from mouse embryonic stem cells and brain
T Amort, D Rieder, A Wille, D Khokhlova-Cubberley… - Genome biology, 2017 - Springer
Background Recent work has identified and mapped a range of posttranscriptional
modifications in mRNA, including methylation of the N6 and N1 positions in adenine, …
modifications in mRNA, including methylation of the N6 and N1 positions in adenine, …
[HTML][HTML] Neoantigens generated by individual mutations and their role in cancer immunity and immunotherapy
Recent preclinical and clinical studies have proved the long-standing hypothesis that tumors
elicit adaptive immune responses and that the antigens driving effective T-cell response are …
elicit adaptive immune responses and that the antigens driving effective T-cell response are …
Scirpy: a Scanpy extension for analyzing single-cell T-cell receptor-sequencing data
Advances in single-cell technologies have enabled the investigation of T-cell phenotypes
and repertoires at unprecedented resolution and scale. Bioinformatic methods for the efficient …
and repertoires at unprecedented resolution and scale. Bioinformatic methods for the efficient …
Deconvoluting tumor-infiltrating immune cells from RNA-seq data using quanTIseq
C Plattner, F Finotello, D Rieder - Methods in enzymology, 2020 - Elsevier
Tumor-infiltrating immune cells comprise various cells of the innate and the adaptive immune
system, which influence tumor growth and response to immunotherapy by exerting anti- …
system, which influence tumor growth and response to immunotherapy by exerting anti- …
Next-generation computational tools for interrogating cancer immunity
The remarkable success of cancer therapies with immune checkpoint blockers is
revolutionizing oncology and has sparked intensive basic and translational research into the …
revolutionizing oncology and has sparked intensive basic and translational research into the …