Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to
antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called …

Peutz-Jeghers (PJ) syndrome is an autosomal-dominant disorder characterized by melanocytic
macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased …

Polymorphonuclear neutrophils are the first cells recruited to inflammatory sites and form the
earliest line of defense against invading microorganisms. Neutrophil elastase, proteinase 3, …

Homing behavior and function of autoimmune CD4 + T cells in vivo was analyzed before
and during EAE, using MBP-specific T cells retrovirally engineered to express the gene of …

Whether neurons express major histocompatibility complex (MHC) class I genes has not
been firmly established. The techniques of confocal laser microscopy, patch clamp …

A component of soluble terminal complement complexes was identified and affinity-purified
to homogeneity by using a monoclonal antibody previously developed against the soluble …

Neutrophil granulocytes form the body’s first line of antibacterial defense, but they also
contribute to tissue injury and noninfectious, chronic inflammation. Proteinase 3 (PR3) and …

Whether B cells serve as antigen-presenting cells (APCs) for activation of pathogenic T cells
in the multiple sclerosis model experimental autoimmune encephalomyelitis (EAE) is …

Autosomal recessive limb-girdle muscular dystrophies (AR LGMDs) are a genetically
heterogeneous group of disorders that affect mainly the proximal musculature 1. There are eight …

A PROTEIN that could aggregate Sertoli cells in vitro was purified to homogeneity from ram
rete testis fluid by Fritz and collaborators in 1983]. This protein also elicited the clustering of …