Mechanisms of β-cell death in type 2 diabetes

MY Donath, JA Ehses, K Maedler, DM Schumann… - Diabetes, 2005 - Am Diabetes Assoc
… Because hyperglycemia regulates Fas expression (11,22), we hypothesized that the Fas
pathway may not solely mediate glucose-induced changes in cell turnover, but also changes in …

Islet inflammation in type 2 diabetes: from metabolic stress to therapy

MY Donath, DM Schumann, M Faulenbach… - Diabetes …, 2008 - Am Diabetes Assoc
… We tested the hypothesis that IL-1β may mediate the deleterious effects of high glucose
on human β-cells (6). In vitro exposure of islets from nondiabetic organ donors to high …

[HTML][HTML] Current relevance of hypoxia in head and neck cancer

…, I El-Kochairi, Y Dahlem, K Ikenberg, DM Schumann - Oncotarget, 2016 - ncbi.nlm.nih.gov
Head and Neck cancer (HNC) is a complex mix of cancers and one of the more common
cancers with a relatively poor prognosis. One of the factors that may assist us in predicting …

Aging correlates with decreased β-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1

K Maedler, DM Schumann, F Schulthess… - Diabetes, 2006 - Am Diabetes Assoc
Type 2 diabetes is characterized by a deficit in β-cell mass, and its incidence increases with
age. Here, we analyzed β-cell turnover in islets from 2- to 3- compared with 7- to 8-month-…

Low concentration of interleukin-1β induces FLICE-inhibitory protein–mediated β-cell proliferation in human pancreatic islets

K Maedler, DM Schumann, N Sauter, H Ellingsgaard… - Diabetes, 2006 - Am Diabetes Assoc
… Since glucose induces IL-1β, we hypothesized that IL-1β may also mediate beneficial
effects of glucose. We show that low concentrations of IL-1β induce β-cell proliferation and …

[HTML][HTML] Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice

S Wueest, RA Rapold, DM Schumann… - The Journal of …, 2010 - Am Soc Clin Investig
… Since Fas is expressed in preadipocytes and adipocytes (18), and since adipose tissue
inflammation may be causatively linked to insulin resistance, we hypothesized that Fas …

Stability of the blood eosinophilic phenotype in stable and exacerbated COPD

DM Schumann, M Tamm, K Kostikas, D Stolz - Chest, 2019 - Elsevier
… Studies have shown that a blood eosinophil level ≥ 2% may be a predictor for response
to ICS treatment on top of a long-acting β 2 -agonist5, 6; a cutoff of 300 cells/μL has been …

Interleukin-1 beta targeted therapy for type 2 diabetes

…, G Dharmadhikari, DM Schumann… - Expert opinion on …, 2009 - Taylor & Francis
Since having been cloned in 1984, IL-1β has been the subject of over 22,000 citations in
Pubmed, among them over 800 reviews. This is because of its numerous effects. IL-1β is a …

Collagen degradation and formation are elevated in exacerbated COPD compared with stable disease

DM Schumann, D Leeming, E Papakonstantinou… - Chest, 2018 - Elsevier
… Pathology-related changes in ECM turnover may result in deleterious changes in lung
architecture, leading to disease in the small airways. Here, degradation fragments of type I (C1M), …

Fast multiplex bacterial PCR of bronchoalveolar lavage for antibiotic stewardship in hospitalised patients with pneumonia at risk of Gram-negative bacterial infection …

…, S Bassetti, M Osthoff, DM Schumann… - The Lancet …, 2022 - thelancet.com
Background PCR-based testing has transformed the management of suspected respiratory
viral infections. We aimed to determine whether multiplex bacterial PCR of bronchoalveolar …