The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor

GS Tjabringa, J Aarbiou, DK Ninaber… - The Journal of …, 2003 - journals.aai.org
Antimicrobial peptides produced by epithelial cells and neutrophils represent essential
elements of innate immunity, and include the defensin and cathelicidin family of antimicrobial …

Human cathelicidin LL-37 is a chemoattractant for eosinophils and neutrophils that acts via formyl-peptide receptors

GS Tjabringa, DK Ninaber, JW Drijfhout… - International archives of …, 2006 - karger.com
Background: Inflammatory lung diseases such as asthma and chronic obstructive pulmonary
disease (COPD) are characterized by the presence of eosinophils and neutrophils. …

Suramin inhibits SARS-CoV-2 infection in cell culture by interfering with early steps of the replication cycle

…, NS Ogando, PJ Bredenbeek, DK Ninaber… - Antimicrobial Agents …, 2020 - Am Soc Microbiol
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic that
originated in Wuhan, China, in December 2019 has impacted public health, society, the global …

[HTML][HTML] Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of …

…, GG Johnson, TJ Dalebout, DK Ninaber… - Journal of Biological …, 2014 - ASBMB
Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging human
pathogen that was first isolated in 2012. MERS-CoV replication depends in part on a virus-…

Arterivirus and nairovirus ovarian tumor domain-containing deubiquitinases target activated RIG-I to control innate immune signaling

PB van Kasteren, C Beugeling, DK Ninaber… - Journal of …, 2012 - Am Soc Microbiol
The innate immune response constitutes the first line of defense against viral infection and is
extensively regulated through ubiquitination. The removal of ubiquitin from innate immunity …

Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells

…, TW James, DK Ninaber… - Proceedings of the …, 2013 - National Acad Sciences
Protein ubiquitination regulates important innate immune responses. The discovery of
viruses encoding deubiquitinating enzymes (DUBs) suggests they remove ubiquitin to evade …

Metabolic engineering toward sustainable production of nylon-6

SCHJ Turk, WP Kloosterman, DK Ninaber… - ACS synthetic …, 2016 - ACS Publications
Nylon-6 is a bulk polymer used for many applications. It consists of the non-natural building
block 6-aminocaproic acid, the linear form of caprolactam. Via a retro-synthetic approach, …

The antimicrobial peptide LL-37 enhances IL-8 release by human airway smooth muscle cells

S Zuyderduyn, DK Ninaber, PS Hiemstra… - Journal of allergy and …, 2006 - Elsevier
BACKGROUND: Human airway smooth muscle (HASM) cells release various chemokines
that are involved in recruitment of inflammatory cells, which can be found within or in the …

[HTML][HTML] In vitro modelling of alveolar repair at the air-liquid interface using alveolar epithelial cells derived from human induced pluripotent stem cells

S van Riet, DK Ninaber, HMM Mikkers, TD Tetley… - Scientific reports, 2020 - nature.com
Research on acute and chronic lung diseases would greatly benefit from reproducible
availability of alveolar epithelial cells (AEC). Primary alveolar epithelial cells can be derived from …

Aberrant epithelial differentiation by cigarette smoke dysregulates respiratory host defence

…, TCJ Mertens, DK Ninaber… - European …, 2018 - Eur Respiratory Soc
It is currently unknown how cigarette smoke-induced airway remodelling affects highly expressed
respiratory epithelial defence proteins and thereby mucosal host defence. Localisation …