Increased angiotensin-converting enzyme 2 and loss of alveolar type II cells in COVID-19–related acute respiratory distress syndrome

L Gerard, M Lecocq, C Bouzin, D Hoton… - American journal of …, 2021 - atsjournals.org
Rationale: ACE2 (angiotensin-converting enzyme 2), the entry receptor for severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is expressed in type 2 alveolar epithelial …

[HTML][HTML] Short telomeres increase the risk of severe COVID-19

A Froidure, M Mahieu, D Hoton, PF Laterre… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Telomeres are non-coding DNA sequences that protect chromosome ends and shorten with
age. Short telomere length (TL) is associated with chronic diseases and immunosenescence…

[HTML][HTML] Altered generation of ciliated cells in chronic obstructive pulmonary disease

…, M Lecocq, MZ Ladjemi, S Verleden, D Hoton… - Scientific reports, 2019 - nature.com
In COPD, epithelial changes are prominent features in the airways, such as goblet cell
hyperplasia and squamous metaplasia. In contrast, it remains unclear whether ciliated cells are …

[HTML][HTML] Antibiotic-exposed patients with non-small-cell lung cancer preserve efficacy outcomes following first-line chemo-immunotherapy

…, A Barba, JC Benitez, T Gorría, L Mezquita, D Hoton… - Annals of …, 2021 - Elsevier
Background Prior antibiotic therapy (pATB) is known to impair efficacy of single-agent immune
checkpoint inhibitors (ICIs), potentially through the induction of gut dysbiosis. Whether …

[HTML][HTML] Canonical WNT pathway is activated in the airway epithelium in chronic obstructive pulmonary disease

…, JL Gala, C Bouzin, SE Verleden, D Hoton… - …, 2020 - thelancet.com
Background Chronic obstructive pulmonary disease (COPD) is a devastating lung disease,
mainly due to cigarette smoking, which represents the third cause of mortality worldwide. The …

[HTML][HTML] Real-life prevalence of progressive fibrosing interstitial lung diseases

M Gagliardi, DV Berg, CE Heylen, S Koenig, D Hoton… - Scientific reports, 2021 - nature.com
The concept of progressive fibrosing interstitial lung disease (PF-ILD) has recently emerged.
However, real-life proportion of PF-ILDs outside IPF is still hard to evaluate. Therefore, we …

[HTML][HTML] Chilblains and COVID‐19: why SARS‐CoV‐2 endothelial infection is questioned

M Baeck, D Hoton, L Marot… - The British journal of …, 2020 - ncbi.nlm.nih.gov
Recently, Colmenero et al. 1 demonstrated, by immunohistochemistry and by electron
microscopy (EM), the presence of SARS-CoV-2 in endothelial cells of skin biopsy specimens of …

[HTML][HTML] Increased expression and activation of FAK in small-cell lung cancer compared to non-small-cell lung cancer

F Aboubakar Nana, D Hoton, J Ambroise, M Lecocq… - Cancers, 2019 - mdpi.com
Introduction: Focal adhesion kinase (FAK) plays a crucial role in cancer development and
progression. FAK is overexpressed and/or activated and associated with poor prognosis in …

[HTML][HTML] Lung immunoglobulin A immunity dysregulation in cystic fibrosis

…, V De Rose, L Regard, C Martin, PR Burgel, D Hoton… - …, 2020 - thelancet.com
Background In cystic fibrosis (CF), recurrent infections suggest impaired mucosal immunity
but whether production of secretory immunoglobulin A (S-IgA) is impaired remains elusive. S-…

[HTML][HTML] Loss of ciliated cells and altered airway epithelial integrity in cystic fibrosis

…, FM Carlier, C Bouzin, P De Sany, D Hoton… - Journal of Cystic …, 2021 - Elsevier
Background In cystic fibrosis, the respiratory epithelium is the target tissue of both the
genetic abnormality of the disease and of external aggressions, notably by pathogens (…