Increased angiotensin-converting enzyme 2 and loss of alveolar type II cells in COVID-19–related acute respiratory distress syndrome
L Gerard, M Lecocq, C Bouzin, D Hoton… - American journal of …, 2021 - atsjournals.org
Rationale: ACE2 (angiotensin-converting enzyme 2), the entry receptor for severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is expressed in type 2 alveolar epithelial …
respiratory syndrome coronavirus 2 (SARS-CoV-2), is expressed in type 2 alveolar epithelial …
[HTML][HTML] Short telomeres increase the risk of severe COVID-19
A Froidure, M Mahieu, D Hoton, PF Laterre… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Telomeres are non-coding DNA sequences that protect chromosome ends and shorten with
age. Short telomere length (TL) is associated with chronic diseases and immunosenescence…
age. Short telomere length (TL) is associated with chronic diseases and immunosenescence…
[HTML][HTML] Altered generation of ciliated cells in chronic obstructive pulmonary disease
…, M Lecocq, MZ Ladjemi, S Verleden, D Hoton… - Scientific reports, 2019 - nature.com
In COPD, epithelial changes are prominent features in the airways, such as goblet cell
hyperplasia and squamous metaplasia. In contrast, it remains unclear whether ciliated cells are …
hyperplasia and squamous metaplasia. In contrast, it remains unclear whether ciliated cells are …
[HTML][HTML] Antibiotic-exposed patients with non-small-cell lung cancer preserve efficacy outcomes following first-line chemo-immunotherapy
…, A Barba, JC Benitez, T Gorría, L Mezquita, D Hoton… - Annals of …, 2021 - Elsevier
Background Prior antibiotic therapy (pATB) is known to impair efficacy of single-agent immune
checkpoint inhibitors (ICIs), potentially through the induction of gut dysbiosis. Whether …
checkpoint inhibitors (ICIs), potentially through the induction of gut dysbiosis. Whether …
[HTML][HTML] Canonical WNT pathway is activated in the airway epithelium in chronic obstructive pulmonary disease
…, JL Gala, C Bouzin, SE Verleden, D Hoton… - …, 2020 - thelancet.com
Background Chronic obstructive pulmonary disease (COPD) is a devastating lung disease,
mainly due to cigarette smoking, which represents the third cause of mortality worldwide. The …
mainly due to cigarette smoking, which represents the third cause of mortality worldwide. The …
[HTML][HTML] Real-life prevalence of progressive fibrosing interstitial lung diseases
M Gagliardi, DV Berg, CE Heylen, S Koenig, D Hoton… - Scientific reports, 2021 - nature.com
The concept of progressive fibrosing interstitial lung disease (PF-ILD) has recently emerged.
However, real-life proportion of PF-ILDs outside IPF is still hard to evaluate. Therefore, we …
However, real-life proportion of PF-ILDs outside IPF is still hard to evaluate. Therefore, we …
[HTML][HTML] Chilblains and COVID‐19: why SARS‐CoV‐2 endothelial infection is questioned
M Baeck, D Hoton, L Marot… - The British journal of …, 2020 - ncbi.nlm.nih.gov
Recently, Colmenero et al. 1 demonstrated, by immunohistochemistry and by electron
microscopy (EM), the presence of SARS-CoV-2 in endothelial cells of skin biopsy specimens of …
microscopy (EM), the presence of SARS-CoV-2 in endothelial cells of skin biopsy specimens of …
[HTML][HTML] Increased expression and activation of FAK in small-cell lung cancer compared to non-small-cell lung cancer
F Aboubakar Nana, D Hoton, J Ambroise, M Lecocq… - Cancers, 2019 - mdpi.com
Introduction: Focal adhesion kinase (FAK) plays a crucial role in cancer development and
progression. FAK is overexpressed and/or activated and associated with poor prognosis in …
progression. FAK is overexpressed and/or activated and associated with poor prognosis in …
[HTML][HTML] Lung immunoglobulin A immunity dysregulation in cystic fibrosis
Background In cystic fibrosis (CF), recurrent infections suggest impaired mucosal immunity
but whether production of secretory immunoglobulin A (S-IgA) is impaired remains elusive. S-…
but whether production of secretory immunoglobulin A (S-IgA) is impaired remains elusive. S-…
[HTML][HTML] Loss of ciliated cells and altered airway epithelial integrity in cystic fibrosis
…, FM Carlier, C Bouzin, P De Sany, D Hoton… - Journal of Cystic …, 2021 - Elsevier
Background In cystic fibrosis, the respiratory epithelium is the target tissue of both the
genetic abnormality of the disease and of external aggressions, notably by pathogens (…
genetic abnormality of the disease and of external aggressions, notably by pathogens (…